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Association Between Achievement of Clinical Disease Control and Improvement in Patient‐Reported Outcomes and Quality of Life in Patients With Psoriatic Arthritis in the Phase 3 SELECT‐PsA 1 and 2 Randomized Controlled Trials

dc.contributor.authorArthur Kavanaugh
dc.contributor.authorPhilip Mease
dc.contributor.authorLaure Gossec
dc.contributor.authorRoberto Ranza
dc.contributor.authorShigeyoshi Tsuji
dc.contributor.authorKevin Douglas
dc.contributor.authorMichael Lane
dc.contributor.authorRalph Lippe
dc.contributor.authorManish Mittal
dc.contributor.authorTianming Gao
dc.contributor.authorArathi Setty
dc.contributor.authorSandra Ciecinski
dc.contributor.authorDaniel Aletaha
dc.contributor.authorPeter Nash
dc.contributor.otherUniversity of California San Diego
dc.contributor.otherSwedish Medical Center/Providence St. Joseph Health and University of Washington Seattle
dc.contributor.otherSorbonne Université, INSERM, and Pitié‐Salpêtrière Hospital, AP‐HP Paris France
dc.contributor.otherHospital de Clinicas Universidade Federal de Uberlândia Uberlândia Brazil
dc.contributor.otherNippon Life Hospital Osaka Japan
dc.contributor.otherAbbVie Inc North Chicago Illinois
dc.contributor.otherAbbVie Inc North Chicago Illinois
dc.contributor.otherAbbVie Inc North Chicago Illinois
dc.contributor.otherAbbVie Inc North Chicago Illinois
dc.contributor.otherAbbVie Inc North Chicago Illinois
dc.contributor.otherAbbVie Inc North Chicago Illinois
dc.contributor.otherAbbVie Inc North Chicago Illinois
dc.contributor.otherMedical University of Vienna Vienna Austria
dc.contributor.otherGriffith University and Rheumatology Research Unit, Sunshine Coast Brisbane Queensland Australia
dc.date.accessioned2025-10-09T04:53:04Z
dc.date.available2025-10-09T04:53:04Z
dc.date.issued01-11-2024
dc.identifier.urihttps://doi.org/10.1002/acr2.11714
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/40820
dc.description.abstractObjective We explored the relationship between achievement of clinical disease control and improvements in and normative values for patient‐reported outcomes (PROs), including quality of life (QoL) measures, in patients with psoriatic arthritis (PsA). Methods This was a post hoc analysis of 104‐week data from the SELECT‐PsA 1 and 2 trials in adults with PsA and inadequate response to one or more conventional synthetic (SELECT‐PsA 1) or biologic (SELECT‐PsA 2) disease‐modifying antirheumatic drug. Patients were initially randomized to upadacitinib 15 mg once daily (QD) to placebo switched to upadacitinib 15 mg QD at week 24 or to adalimumab 40 mg every other week (SELECT‐PsA 1 only), and data were pooled across treatments and analyzed. We evaluated several clinical disease control measures (minimal disease activity [MDA]; very low disease activity [VLDA]; and low disease activity [LDA] and/or remission by Disease Activity in Psoriatic Arthritis [DAPSA], Psoriatic Arthritis Disease Activity Score [PASDAS], and Routine Assessment of Patient Index Data 3 [RAPID3]) and examined their associations with improvements and normative values for various PROs. Results A total of 1,069 and 317 patients were analyzed for SELECT‐PsA 1 and 2, respectively. In both studies, responders (patients who achieved MDA or VLDA, and DAPSA, PASDAS, and RAPID3 LDA or remission) at week 104 achieved more marked changes from baseline, and more responders achieved normative values in PROs compared with nonresponders (most nominal P < 0.0001). Furthermore, numerically larger proportions of responders achieved minimal clinically important differences across PROs compared with nonresponders in both studies. In addition, patients who achieved MDA or VLDA were more likely to achieve DAPSA, PASDAS, and RAPID3 LDA or remission (all nominal P < 0.0001) for upadacitinib 15 mg QD and when treatment arms were pooled. Conclusion Patients with PsA who achieve clinical disease control are more likely to achieve improvements and normative values in PROs and QoL measures, which reinforces disease control as a treatment target.
dc.language.isoEN
dc.publisherWiley
dc.subject.lccDiseases of the musculoskeletal system
dc.titleAssociation Between Achievement of Clinical Disease Control and Improvement in Patient‐Reported Outcomes and Quality of Life in Patients With Psoriatic Arthritis in the Phase 3 SELECT‐PsA 1 and 2 Randomized Controlled Trials
dc.typeArticle
dc.description.pages736-745
dc.description.doi10.1002/acr2.11714
dc.title.journalACR Open Rheumatology
dc.identifier.e-issn2578-5745
dc.identifier.oaioai:doaj.org/journal:68885dcde7f34e47b390d4e348fea563
dc.journal.infoVolume 6, Issue 11


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