| dc.contributor.author | Soo Ran Choi | |
| dc.contributor.author | Soon-Sun Hong | |
| dc.contributor.author | Juyoung Kim | |
| dc.contributor.author | Keun-Young Lee | |
| dc.contributor.other | Department of Obstetrics and Gynecology, Inha University College of Medicine, Incheon, South Korea | |
| dc.contributor.other | Department of New Drug Development, Inha University College of Medicine, Incheon, South Korea | |
| dc.contributor.other | Department of New Drug Development, Inha University College of Medicine, Incheon, South Korea | |
| dc.contributor.other | Department of Obstetrics and Gynecology, Hallym University College of Medicine, Kangnam Sacred Heart Hospital, Seoul, South Korea | |
| dc.date.accessioned | 2025-10-09T04:53:14Z | |
| dc.date.available | 2025-10-09T04:53:14Z | |
| dc.date.issued | 01-06-2018 | |
| dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S1028455918300809 | |
| dc.identifier.uri | http://digilib.fisipol.ugm.ac.id/repo/handle/15717717/40822 | |
| dc.description.abstract | Objective: The aim of the study was to determine the relationships between short cervical length (CL) and levels of cervical fluid neutrophil elastase (NE), secretory leukocyte protease inhibitor (SLPI), and interleukin 8 (IL-8) in the second trimester of pregnancy of women who underwent ultrasound-indicated cervical cerclage.
Materials and methods: CL of <25 mm or cervical funneling were included in the short CL group (n = 26) and the normal CL group (n = 22) included women who had CL of ≥25 mm and had no cervical funneling in women between 17 + 0 and 24 + 6 weeks of gestation. Levels of NE, SLPI, and IL-8 were measured by using enzyme-linked immunosorbent assay kits. Mann–Whitney U tests and Spearman's correlation analysis were used for statistical analyses.
Results: Compared with the normal CL group, the short CL group had significantly higher median NE levels (P < 0.001) and higher, though not significant, median IL-8 levels by approximately three times (2107.0 vs. 798.3 pg/mL, P = 0.132). The median SLPI levels in cervical fluid was similar between the two groups (107.6 vs. 103.2 ng/mL, P = 0.499). Short CL had a significant correlations with cervical fluid NE levels (r = −0.475, P = 0.001).
Conclusion: Increased cervical fluid NE associated with cervical shortening in second trimester of pregnancy, whereas cervical fluid SLPI had constant levels. | |
| dc.language.iso | EN | |
| dc.publisher | Elsevier | |
| dc.subject.lcc | Gynecology and obstetrics | |
| dc.title | Neutrophil elastase in cervical fluid in women with short cervical length | |
| dc.type | Article | |
| dc.description.keywords | Neutrophil elastase | |
| dc.description.keywords | Preterm birth | |
| dc.description.keywords | Secretory leukocyte protease inhibitor | |
| dc.description.keywords | Short cervix | |
| dc.description.pages | 407-410 | |
| dc.description.doi | 10.1016/j.tjog.2018.04.014 | |
| dc.title.journal | Taiwanese Journal of Obstetrics & Gynecology | |
| dc.identifier.oai | oai:doaj.org/journal:1cd832111e6047b0905bb11882c90768 | |
| dc.journal.info | Volume 57, Issue 3 | |
