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Physiology and Pathophysiology of Proteinase-Activated Receptors (PARs): Regulation of the Expression of PARs

dc.contributor.authorKatsuya Hirano
dc.contributor.authorTatsuya Yufu
dc.contributor.authorMayumi Hirano
dc.contributor.authorJunji Nishimura
dc.contributor.authorHideo Kanaide
dc.contributor.otherDivision of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University and
dc.contributor.otherDivision of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University and
dc.contributor.otherDivision of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University and
dc.contributor.otherDivision of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University and
dc.contributor.otherDivision of Molecular Cardiology, Research Institute of Angiocardiology, Graduate School of Medical Sciences, Kyushu University and; Kyushu University COE Program on Lifestyle-Related Diseases, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan; Corresponding author (affiliation #1). FAX: +81-92-642-5552 E-mail: kanaide@molcar.med.kyushu-u.ac.jp
dc.date.accessioned2025-10-09T04:53:33Z
dc.date.available2025-10-09T04:53:33Z
dc.date.issued01-01-2005
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S134786131932290X
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/40826
dc.description.abstractThe level of receptors expressed on the cell surface determines the cellular responsiveness to agonists. Proteinase-activated receptors (PARs) have been reported to be either upregulated or down-regulated in response to various types of stimulation and pathological situations. In addition, the transcriptional regulation plays a major role in the alteration of the expression of PARs under pathological conditions, while post-translational mechanisms such as phosphorylation, arresting-binding, internalization, and lysosomal degradation, which desensitize activated PARs and terminate intracellular signaling, also play an important role in regulating the expression of PARs and the cellular responsiveness to the agonists. Elucidating the mechanisms related to the expression of PARs is a critical step to understand the pathophysiology of various diseases and establish new therapeutic strategies. However, the molecular mechanism regulating the expression of PARs still remains to be elucidated. This minireview discusses our current understanding of the mechanisms regulating the expression of PARs. The transcription factors and the regulatory elements in the promoter regions, and the proteins that interact with the receptors and thereby regulate their trafficking and desensitization are the main problems that need to be elucidated. Keywords:: expression, transcription, trafficking, proteinase-activated receptor
dc.language.isoEN
dc.publisherElsevier
dc.subject.lccTherapeutics. Pharmacology
dc.titlePhysiology and Pathophysiology of Proteinase-Activated Receptors (PARs): Regulation of the Expression of PARs
dc.typeArticle
dc.description.pages31-37
dc.description.doi10.1254/jphs.fmj04005x6
dc.title.journalJournal of Pharmacological Sciences
dc.identifier.oaioai:doaj.org/journal:1ceff26db7944a808359989e877cd54e
dc.journal.infoVolume 97, Issue 1


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