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The efficacy and safety of ECMO and CPB in lung transplantation: A systematic review and meta-analysis

dc.contributor.authorYongming Ma
dc.contributor.authorYuhan Geng
dc.contributor.authorDong Wang
dc.contributor.authorZhiqiang Wu
dc.contributor.authorXiaogang Yang
dc.contributor.authorLong Ma
dc.contributor.authorRuitong Chang
dc.contributor.authorBaowei Meng
dc.contributor.authorZijiang Zhu
dc.contributor.otherDepartment of Thoracic Surgery, Gansu Provincial Maternity and Child Health Care Hospital (Gansu Provincial Central Hospital), Lanzhou, China
dc.contributor.otherFirst Clinical Medical College, Ningxia Medical University, Yinchuan, China
dc.contributor.otherThoracic Surgery Department, Zhangye People's Hospital Affiliated to Hexi University, Zhangye, China
dc.contributor.otherDepartment of Thoracic Surgery, Gansu Provincial Maternity and Child Health Care Hospital (Gansu Provincial Central Hospital), Lanzhou, China
dc.contributor.otherDepartment of Thoracic Surgery, Gansu Provincial Maternity and Child Health Care Hospital (Gansu Provincial Central Hospital), Lanzhou, China
dc.contributor.otherDepartment of Thoracic Surgery, Gansu Provincial Maternity and Child Health Care Hospital (Gansu Provincial Central Hospital), Lanzhou, China
dc.contributor.otherDepartment of Thoracic Surgery, Gansu Provincial Maternity and Child Health Care Hospital (Gansu Provincial Central Hospital), Lanzhou, China
dc.contributor.otherDepartment of Thoracic Surgery, Gansu Provincial Maternity and Child Health Care Hospital (Gansu Provincial Central Hospital), Lanzhou, China
dc.contributor.otherDepartment of Thoracic Surgery, Gansu Provincial Maternity and Child Health Care Hospital (Gansu Provincial Central Hospital), Lanzhou, China; Corresponding author.
dc.date.accessioned2025-10-09T04:55:23Z
dc.date.available2025-10-09T04:55:23Z
dc.date.issued01-07-2025
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S1015958425005603
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/40842
dc.description.abstractTo systematically evaluate the efficacy and safety of Extracorporeal Membrane Oxygenation (ECMO) and Cardiopulmonary Bypass (CPB) in lung transplantation, we searched databases including PubMed, EMbase, The Cochrane Library, Web of Science, and CNKI. We used Review Manager V5.3 software for meta-analysis of the literature. A total of 10 retrospective studies were included, covering 1158 clinical patients (535 in the ECMO group and 623 in the CPB group). Compared to CPB, ECMO showed less intraoperative platelet demand [MD = −3.32, 95 % CI (−3.58, −3.06), P < 0.0001]; shorter ICU stay times [MD = −4.33, 95 % CI (−7.76, −0.90), P = 0.01]; and lower incidences of complications such as tracheotomy [OR = 0.52, 95 % CI (0.33, 0.81), P = 0.004], renal failure [OR = 0.53, 95 % CI (0.36, 0.77), P = 0.0009], and secondary surgeries [OR = 0.27, 95 % CI (0.16, 0.46), P < 0.00001], all statistically significant. However, no significant differences were observed in postoperative mortality rates (at 1 month, 3 months, and 1 year) or other transfusion requirements between the two groups. Our analysis suggests that compared to CPB (Cardiopulmonary Bypass), ECMO (Extracorporeal Membrane Oxygenation) can reduce ICU stay and intraoperative platelet requirements, while also decreasing the incidence of tracheostomy, renal failure, and secondary surgeries. Although ECMO shows advantages in several clinical indicators, its long-term postoperative survival rate is similar to that of CPB. When choosing ECMO as a support technology for lung transplantation, various factors should be considered comprehensively. More research is needed to further clarify which patient populations benefit from which type of extracorporeal support technology.
dc.language.isoEN
dc.publisherElsevier
dc.subject.lccSurgery
dc.titleThe efficacy and safety of ECMO and CPB in lung transplantation: A systematic review and meta-analysis
dc.typeArticle
dc.description.keywordsECMO
dc.description.keywordsCPB
dc.description.keywordsLung transplantation
dc.description.keywordsSystematic review/meta-analysis
dc.description.pages4115-4122
dc.description.doi10.1016/j.asjsur.2025.03.002
dc.title.journalAsian Journal of Surgery
dc.identifier.oaioai:doaj.org/journal:1d9ae64869434c63a4aecfbfd3a71247
dc.journal.infoVolume 48, Issue 7


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