| dc.contributor.author | Lizette Anayo | |
| dc.contributor.author | Paula Rogers | |
| dc.contributor.author | Linda Long | |
| dc.contributor.author | Miles Dalby | |
| dc.contributor.author | Rod Taylor | |
| dc.contributor.other | 2 Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK | |
| dc.contributor.other | Royal Brompton & Harefield NHS Foundation Trust Hospital, Uxbridge, UK | |
| dc.contributor.other | Institute of Health Research, University of Exeter Medical School, Exeter, UK | |
| dc.contributor.other | Royal Brompton & Harefield NHS Foundation Trust, London, UK | |
| dc.contributor.other | MRC/CSO Social and Public Health Sciences Unit & Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK | |
| dc.date.accessioned | 2025-10-09T05:15:13Z | |
| dc.date.available | 2025-10-09T05:15:13Z | |
| dc.date.issued | 01-May-2019 | |
| dc.identifier.uri | https://openheart.bmj.com/content/6/1/e000922.full | |
| dc.identifier.uri | http://digilib.fisipol.ugm.ac.id/repo/handle/15717717/40880 | |
| dc.description.abstract | Objectives Exercise-based cardiac rehabilitation (CR) may be beneficial to patients following transcatheter aortic valve implantation (TAVI) and open surgical aortic valve replacement (SAVR). We aimed to undertake a systematic review and meta-analysis to evaluate the efficacy, safety and costs of exercise-based CR post-TAVI and post-SAVR.Methods We searched numerous databases, including Embase, CENTRAL and MEDLINE, up to October 2017. We included randomised controlled trials (RCTs) and non-randomised controlled trials (non-RCTs) of exercise-based CR compared with no exercise control in TAVI or SAVR patients ≥18 years. Data extraction and risk of bias assessments were performed independently by two reviewers. Narrative synthesis and meta-analysis (where appropriate) were carried out for all relevant outcomes, and a Grading of Recommendations Assessment, Development and Evaluation (GRADE) analysis was also performed.Results Six studies, all at low risk of bias, were included: three RCTs and three non-RCTs (total of 27 TAVI, 99 SAVR and 129 mixed patients), with follow-up of 2–12 months. There was an increase in pooled exercise capacity (standardised mean difference: 0.41, 95% CI 0.11 to 0.70; moderate certainty evidence as assessed by GRADE), with exercise-based rehabilitation compared with control. Data on other outcomes including quality of life and clinical events were limited.Conclusions Exercise-based CR probably improves exercise capacity of post-TAVI and post-SAVR patients in the short term. Well conducted multicentre fully powered RCTs of ≥12 months follow-up are needed to fully assess the clinical and cost-effectiveness of exercise-based CR in this patient population.PROSPERO Protocol Registration Number CRD42017084716. | |
| dc.language.iso | EN | |
| dc.publisher | BMJ Publishing Group | |
| dc.subject.lcc | Diseases of the circulatory (Cardiovascular) system | |
| dc.title | Exercise-based cardiac rehabilitation for patients following open surgical aortic valve replacement and transcatheter aortic valve implant: a systematic review and meta-analysis | |
| dc.type | Article | |
| dc.description.doi | 10.1136/openhrt-2018-000922 | |
| dc.title.journal | Open Heart | |
| dc.identifier.e-issn | 2053-3624 | |
| dc.identifier.oai | oai:doaj.org/journal:8ab78bd81f1242cc8bfc8a795eb8183f | |
| dc.journal.info | Volume 6, Issue 1 | |
