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Factors associated with health-related quality of life among adults with tetralogy of Fallot

dc.contributor.authorGunnar Engström
dc.contributor.authorChristina Christersson
dc.contributor.authorAnette Sandtröm
dc.contributor.authorCamilla Sandberg
dc.contributor.authorDaniel Rinnström
dc.contributor.authorMikael Dellborg
dc.contributor.authorUlf Thilén
dc.contributor.authorPeder Sörensson
dc.contributor.authorNiels-Erik Nielsen
dc.contributor.authorBengt Johansson
dc.contributor.otherDepartment of Clinical Sciences, Lund University, Malmö, Sweden
dc.contributor.otherDepartment of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden
dc.contributor.other1 Heart Centre and Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
dc.contributor.other1 Heart Centre and Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
dc.contributor.other1 Heart Centre and Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
dc.contributor.otherDepartment of Clinical and Molecular Medicine, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden
dc.contributor.other3 Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden
dc.contributor.otherDepartment of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden
dc.contributor.other5 Department of Medical and Health Sciences, Linköping University, Linköping, Sweden
dc.contributor.otherDepartment of Surgical and Perioperative Sciences, Umeå Universitet, Umea, Sweden
dc.date.accessioned2025-10-09T05:15:39Z
dc.date.available2025-10-09T05:15:39Z
dc.date.issued01-May-2019
dc.identifier.urihttps://openheart.bmj.com/content/6/1/e000932.full
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/40888
dc.description.abstractBackground Due to improved care, the numbers of patients with tetralogy of Fallot (ToF) are increasing. However, long-term morbidity and need for reinterventions are concerns and also address issues of quality of life (QoL).Methods Patients with ToF and valid EuroQol-5 dimensions questionnaire (EQ-5D) were identified in the national Swedish register on congenital heart disease. EQ-5Dindex was calculated and dichotomised into best possible health-related QoL (EQ-5Dindex=1) or differed from 1.Results 288 patients met the criteria and were analysed. Univariate logistic regression showed a positive association between New York Heart Association (NYHA) class I (OR 8.32, 95% CI 3.80 to 18.21), physical activity >3 h/week (OR 3.34, 95% CI 1.67 to 6.66) and a better right ventricular function (OR 2.56, 95% CI 1.09 to 6.02). A negative association between symptoms (OR 0.23, 95% CI 0.13 to 0.42), cardiovascular medication (OR 0.31, 95% CI 0.18 to 0.53), age (OR 0.97, 95% CI 0.96 to 0.99) and EQ-5Dindex was observed. In multivariate logistic regression, NYHA I (OR 7.28, 95% CI 3.29 to 16.12) and physical activity >3 h/week (OR 2.27, 95% CI 1.07 to 4.84) remained associated with best possible health-related QoL. Replacing NYHA with symptoms in the model yielded similar results.Conclusion In this registry study, self-reported physical activity, staff-reported NYHA class and absence of symptoms were strongly associated with best possible health-related QoL measured by EQ-5D. Physical activity level is a potential target for intervention to improve QoL in this population but randomised trials are needed to test such a hypothesis.
dc.language.isoEN
dc.publisherBMJ Publishing Group
dc.subject.lccDiseases of the circulatory (Cardiovascular) system
dc.titleFactors associated with health-related quality of life among adults with tetralogy of Fallot
dc.typeArticle
dc.description.doi10.1136/openhrt-2018-000932
dc.title.journalOpen Heart
dc.identifier.e-issn2053-3624
dc.identifier.oaioai:doaj.org/journal:31f15a6b482944ea8ca2308d259eb2e0
dc.journal.infoVolume 6, Issue 1


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