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Polymer–Colloid Complexes Based on Cationic Imidazolium Amphiphile, Polyacrylic Acid and DNA Decamer

dc.contributor.authorDarya A. Kuznetsova
dc.contributor.authorDinar R. Gabdrakhmanov
dc.contributor.authorDenis M. Kuznetsov
dc.contributor.authorSvetlana S. Lukashenko
dc.contributor.authorValery M. Zakharov
dc.contributor.authorAnastasiia S. Sapunova
dc.contributor.authorSyumbelya K. Amerhanova
dc.contributor.authorAnna P. Lyubina
dc.contributor.authorAlexandra D. Voloshina
dc.contributor.authorDiana V. Salakhieva
dc.contributor.authorLucia Ya. Zakharova
dc.contributor.otherFRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Institute of Organic and Physical Chemistry, Arbuzov str. 8, 420088 Kazan, Russia
dc.contributor.otherFRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Institute of Organic and Physical Chemistry, Arbuzov str. 8, 420088 Kazan, Russia
dc.contributor.otherFRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Institute of Organic and Physical Chemistry, Arbuzov str. 8, 420088 Kazan, Russia
dc.contributor.otherFRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Institute of Organic and Physical Chemistry, Arbuzov str. 8, 420088 Kazan, Russia
dc.contributor.otherKazan National Research Technological University, Karl Marx str., 68, 420015 Kazan, Russia
dc.contributor.otherFRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Institute of Organic and Physical Chemistry, Arbuzov str. 8, 420088 Kazan, Russia
dc.contributor.otherFRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Institute of Organic and Physical Chemistry, Arbuzov str. 8, 420088 Kazan, Russia
dc.contributor.otherFRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Institute of Organic and Physical Chemistry, Arbuzov str. 8, 420088 Kazan, Russia
dc.contributor.otherFRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Institute of Organic and Physical Chemistry, Arbuzov str. 8, 420088 Kazan, Russia
dc.contributor.otherInstitute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, Kremlyovskaya St. 18, 420008 Kazan, Russia
dc.contributor.otherFRC Kazan Scientific Center, Russian Academy of Sciences, Arbuzov Institute of Organic and Physical Chemistry, Arbuzov str. 8, 420088 Kazan, Russia
dc.date.accessioned2025-10-09T05:17:13Z
dc.date.available2025-10-09T05:17:13Z
dc.date.issued01-04-2021
dc.identifier.urihttps://www.mdpi.com/1420-3049/26/8/2363
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/40917
dc.description.abstractThe solution behavior and physicochemical characteristics of polymer–colloid complexes based on cationic imidazolium amphiphile with a dodecyl tail (IA-12) and polyacrylic acid (PAA) or DNA decamer (oligonucleotide) were evaluated using tensiometry, conductometry, dynamic and electrophoretic light scattering and fluorescent spectroscopy and microscopy. It has been established that PAA addition to the surfactant system resulted in a ca. 200-fold decrease in the aggregation threshold of IA-12, with the hydrodynamic diameter of complexes ranging within 100–150 nm. Electrostatic forces are assumed to be the main driving force in the formation of IA-12/PAA complexes. Factors influencing the efficacy of the complexation of IA-12 with oligonucleotide were determined. The nonconventional mode of binding with the involvement of hydrophobic interactions and the intercalation mechanism is probably responsible for the IA-12/oligonucleotide complexation, and a minor contribution of electrostatic forces occurred. The latter was supported by zeta potential measurements and the gel electrophoresis technique, which demonstrated the low degree of charge neutralization of the complexes. Importantly, cellular uptake of the IA-12/oligonucleotide complex was confirmed by fluorescence microscopy and flow cytometry data on the example of M-HeLa cells. While single IA-12 samples exhibit roughly similar cytotoxicity, IA-12–oligonucleotide complexes show a selective effect toward M-HeLa cells (IC<sub>50</sub> 1.1 µM) compared to Chang liver cells (IC<sub>50</sub> 23.1 µM).
dc.language.isoEN
dc.publisherMDPI AG
dc.subject.lccOrganic chemistry
dc.titlePolymer–Colloid Complexes Based on Cationic Imidazolium Amphiphile, Polyacrylic Acid and DNA Decamer
dc.typeArticle
dc.description.keywordsimidazolium
dc.description.keywordsamphiphile
dc.description.keywordspolyacrylic acid
dc.description.keywordsoligonucleotide
dc.description.keywordscomplexation
dc.description.doi10.3390/molecules26082363
dc.title.journalMolecules
dc.identifier.e-issn1420-3049
dc.identifier.oaioai:doaj.org/journal:cd67282f793d47e4a5e32e21a7f29454
dc.journal.infoVolume 26, Issue 8


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