Show simple item record

Optimizing fluconazole-embedded transfersomal gel for enhanced antifungal activity and compatibility studies

dc.contributor.authorZhiqiang Cheng
dc.contributor.authorZhiqiang Cheng
dc.contributor.authorUjjwala Kandekar
dc.contributor.authorXiaoshi Ma
dc.contributor.authorVishal Bhabad
dc.contributor.authorAshlesha Pandit
dc.contributor.authorLiming Liu
dc.contributor.authorJiping Luo
dc.contributor.authorNeha Munot
dc.contributor.authorTrushal Chorage
dc.contributor.authorAbhinandan Patil
dc.contributor.authorSandip Patil
dc.contributor.authorLiang Tao
dc.contributor.otherZhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China
dc.contributor.otherDepartment of Pathology, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China
dc.contributor.otherDepartment of Pharmaceutics, JSPM’s Rajarshi Shahu College of Pharmacy and Research, Pune, Maharashtra, India
dc.contributor.otherDepartment of Pathology, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China
dc.contributor.otherDepartment of Pharmaceutics, JSPM’s Rajarshi Shahu College of Pharmacy and Research, Pune, Maharashtra, India
dc.contributor.otherDepartment of Pharmaceutics, JSPM’s Rajarshi Shahu College of Pharmacy and Research, Pune, Maharashtra, India
dc.contributor.otherDepartment of Pathology, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China
dc.contributor.otherDepartment of Pathology, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China
dc.contributor.otherDepartment of Pharmaceutics, Rajmata Jijau Shikashan Prasarak Mandal College of Pharmacy, Pune, Maharashtra, India
dc.contributor.otherDepartment of Pharmacognosy, JSPM’s Charak College of Pharmacy and Research, Pune, Maharashtra, India
dc.contributor.otherDepartment of Pharmaceutics, D. Y. Patil Education Society, Kolhapur, Maharashtra, India
dc.contributor.otherDepartment of Haematology and Oncology, Shenzhen Children’s Hospital, Shenzhen, China
dc.contributor.otherZhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China
dc.date.accessioned2025-10-09T05:31:18Z
dc.date.available2025-10-09T05:31:18Z
dc.date.issued01-03-2024
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fphar.2024.1353791/full
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/41120
dc.description.abstractFungal infections are of major concern all over the globe, and fluconazole is the most prevalently used drug to treat it. The goal of this research work was to formulate a fluconazole-embedded transfersomal gel for the treatment of fungal infections. A compatibility study between fluconazole and soya lecithin was performed by differential scanning calorimetry (DSC). Transfersomes were formulated by a thin-film hydration technique using soya lecithin and Span 80. A central composite design was adopted to prepare different formulations. Soya lecithin and Span 80 were chosen as independent variables, and the effect of these variables was studied on in vitro drug diffusion. Formulations were evaluated for entrapment efficiency and in vitro drug diffusion. The results of in vitro drug diffusion were analyzed using the analysis of variance (ANOVA) test. Optimized formulation was prepared based on the overlay plot and evaluated by scanning electron microscopy, DSC, vesicle size, polydispersity index (PDI), zeta potential, and in vitro drug diffusion studies. An optimized formulation was loaded into xanthan gum gel base and evaluated for pH, viscosity, in vitro and ex vivo drug diffusion, and antifungal activity. DSC studies revealed compatibility between fluconazole and soya lecithin. Entrapment efficiency and in vitro drug diffusion of various formulations ranged between 89.92% ± 0.20% to 97.28% ± 0.42% and 64% ± 1.56% to 85% ± 2.05%, respectively. A positive correlation was observed between in vitro drug diffusion and Span 80; conversely, a negative correlation was noted with soya lecithin. Entrapment efficiency, particle size, zeta potential, PDI, and drug diffusion of optimized formulation were 95.0% ± 2.2%, 397 ± 2 nm, −38 ± 5 mV, 0.43%, and 81 % ± 2%, respectively. SEM images showed well-distributed spherical-shaped transfersomes. In vitro, ex vivo drug diffusion and antifungal studies were conclusive of better diffusion and enhanced antifungal potential fluconazole in transfersomal formulation.
dc.language.isoEN
dc.publisherFrontiers Media S.A.
dc.subject.lccTherapeutics. Pharmacology
dc.titleOptimizing fluconazole-embedded transfersomal gel for enhanced antifungal activity and compatibility studies
dc.typeArticle
dc.description.keywordstransfersomes
dc.description.keywordsfluconazole
dc.description.keywordstopical application
dc.description.keywordstransfersomal gel
dc.description.keywordsex-vivo studies
dc.description.doi10.3389/fphar.2024.1353791
dc.title.journalFrontiers in Pharmacology
dc.identifier.e-issn1663-9812
dc.identifier.oaioai:doaj.org/journal:ba11dd3609d44995a9e0d1c02dabe1b8


This item appears in the following Collection(s)

Show simple item record