Show simple item record

Frequency-dependent alterations in functional connectivity in patients with Alzheimer’s Disease spectrum disorders

dc.contributor.authorHanjun Hu
dc.contributor.authorHanjun Hu
dc.contributor.authorLuoyu Wang
dc.contributor.authorLuoyu Wang
dc.contributor.authorSammad Abdul
dc.contributor.authorXue Tang
dc.contributor.authorQi Feng
dc.contributor.authorYuzhu Mu
dc.contributor.authorYuzhu Mu
dc.contributor.authorXiuhong Ge
dc.contributor.authorZhengluan Liao
dc.contributor.authorZhongxiang Ding
dc.contributor.otherThe Fourth Clinical College, Zhejiang Chinese Medical University, Hangzhou, China
dc.contributor.otherDepartment of Radiology, Hangzhou First People's Hospital, Hangzhou, China
dc.contributor.otherDepartment of Radiology, Hangzhou First People's Hospital, Hangzhou, China
dc.contributor.otherSchool of Biomedical Engineering, Shanghai Tech University, Shanghai, China
dc.contributor.otherInternational Education College, Zhejiang Chinese Medical University, Hangzhou, China
dc.contributor.otherSchool of Medical Imaging, Hangzhou Medical College, Hangzhou, China
dc.contributor.otherDepartment of Radiology, Hangzhou First People's Hospital, Hangzhou, China
dc.contributor.otherThe Fourth Clinical College, Zhejiang Chinese Medical University, Hangzhou, China
dc.contributor.otherDepartment of Radiology, Hangzhou First People's Hospital, Hangzhou, China
dc.contributor.otherDepartment of Radiology, Hangzhou First People's Hospital, Hangzhou, China
dc.contributor.otherDepartment of Psychiatry, Zhejiang Provincial People’s Hospital/People’s Hospital of Hangzhou Medical College, Hangzhou, China
dc.contributor.otherDepartment of Radiology, Hangzhou First People's Hospital, Hangzhou, China
dc.date.accessioned2025-10-09T05:31:42Z
dc.date.available2025-10-09T05:31:42Z
dc.date.issued01-03-2024
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fnagi.2024.1375836/full
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/41128
dc.description.abstractBackgroundIn the spectrum of Alzheimer’s Disease (AD) and related disorders, the resting-state functional magnetic resonance imaging (rs-fMRI) signals within the cerebral cortex may exhibit distinct characteristics across various frequency ranges. Nevertheless, this hypothesis has not yet been substantiated within the broader context of whole-brain functional connectivity. This study aims to explore potential modifications in degree centrality (DC) and voxel-mirrored homotopic connectivity (VMHC) among individuals with amnestic mild cognitive impairment (aMCI) and AD, while assessing whether these alterations differ across distinct frequency bands.MethodsThis investigation encompassed a total of 53 AD patients, 40 aMCI patients, and 40 healthy controls (HCs). DC and VMHC values were computed within three distinct frequency bands: classical (0.01–0.08 Hz), slow-4 (0.027–0.073 Hz), and slow-5 (0.01–0.027 Hz) for the three respective groups. To discern differences among these groups, ANOVA and subsequent post hoc two-sample t-tests were employed. Cognitive function assessment utilized the mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA). Pearson correlation analysis was applied to investigate the associations between MMSE and MoCA scores with DC and VMHC.ResultsSignificant variations in degree centrality (DC) were observed among different groups across diverse frequency bands. The most notable differences were identified in the bilateral caudate nucleus (CN), bilateral medial superior frontal gyrus (mSFG), bilateral Lobule VIII of the cerebellar hemisphere (Lobule VIII), left precuneus (PCu), right Lobule VI of the cerebellar hemisphere (Lobule VI), and right Lobule IV and V of the cerebellar hemisphere (Lobule IV, V). Likewise, disparities in voxel-mirrored homotopic connectivity (VMHC) among groups were predominantly localized to the posterior cingulate gyrus (PCG) and Crus II of the cerebellar hemisphere (Crus II). Across the three frequency bands, the brain regions exhibiting significant differences in various parameters were most abundant in the slow-5 frequency band.ConclusionThis study enhances our understanding of the pathological and physiological mechanisms associated with AD continuum. Moreover, it underscores the importance of researchers considering various frequency bands in their investigations of brain function.
dc.language.isoEN
dc.publisherFrontiers Media S.A.
dc.subject.lccNeurosciences. Biological psychiatry. Neuropsychiatry
dc.titleFrequency-dependent alterations in functional connectivity in patients with Alzheimer’s Disease spectrum disorders
dc.typeArticle
dc.description.keywordsAlzheimer’s disease
dc.description.keywordsamnestic mild cognitive impairment
dc.description.keywordsresting-state functional magnetic resonance imaging
dc.description.keywordsdegree centrality
dc.description.keywordsvoxel-mirrored homotopic connectivity
dc.description.keywordsslow-5 frequency band
dc.description.doi10.3389/fnagi.2024.1375836
dc.title.journalFrontiers in Aging Neuroscience
dc.identifier.e-issn1663-4365
dc.identifier.oaioai:doaj.org/journal:a09c34dafa5041f29a4c2aa1ba9a4e20


This item appears in the following Collection(s)

Show simple item record