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Long-term outcomes of survivors with influenza A H1N1 virus-induced severe pneumonia and ARDS: a single-center prospective cohort study

dc.contributor.authorXiao Tang
dc.contributor.authorXiao-Li Xu
dc.contributor.authorNa Wan
dc.contributor.authorYu Zhao
dc.contributor.authorRui Wang
dc.contributor.authorXu-Yan Li
dc.contributor.authorYing Li
dc.contributor.authorLi Wang
dc.contributor.authorHai-Chao Li
dc.contributor.authorYue Gu
dc.contributor.authorChun-Yan Zhang
dc.contributor.authorQi Yang
dc.contributor.authorZhao-Hui Tong
dc.contributor.authorBing Sun
dc.contributor.otherDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
dc.contributor.otherDepartment of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
dc.contributor.otherDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
dc.contributor.otherDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
dc.contributor.otherDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
dc.contributor.otherDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
dc.contributor.otherDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
dc.contributor.otherDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
dc.contributor.otherDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
dc.contributor.otherDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
dc.contributor.otherDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
dc.contributor.otherDepartment of Radiology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
dc.contributor.otherDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
dc.contributor.otherDepartment of Respiratory and Critical Care Medicine, Beijing Institute of Respiratory Medicine and Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
dc.date.accessioned2025-10-09T05:32:29Z
dc.date.available2025-10-09T05:32:29Z
dc.date.issued01-03-2024
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fcimb.2024.1378379/full
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/41144
dc.description.abstractIntroductionSystematic evaluation of long-term outcomes in survivors of H1N1 is still lacking. This study aimed to characterize long-term outcomes of severe H1N1-induced pneumonia and acute respiratory distress syndrome (ARDS).MethodThis was a single-center, prospective, cohort study. Survivors were followed up for four times after discharge from intensive care unit (ICU) by lung high-resolution computed tomography (HRCT), pulmonary function assessment, 6-minute walk test (6MWT), and SF-36 instrument.ResultA total of 60 survivors of H1N1-induced pneumonia and ARDS were followed up for four times. The carbon monoxide at single breath (DLCO) of predicted values and the 6MWT results didn’t continue improving after 3 months. Health-related quality of life didn’t change during the 12 months after ICU discharge. Reticulation or interlobular septal thickening on HRCT did not begin to improve significantly until the 12-month follow-up. The DLCO of predicted values showed negative correlation with the severity degree of primary disease and reticulation or interlobular septal thickening, and a positive correlation with physical functioning. The DLCO of predicted values and reticulation or interlobular septal thickening both correlated with the highest tidal volume during mechanical ventilation. Levels of fibrogenic cytokines had a positive correlation with reticulation or interlobular septal thickening.ConclusionThe improvements in pulmonary function and exercise capacity, imaging, and health-related quality of life had different time phase and impact on each other during 12 months of follow-up. Long-term outcomes of pulmonary fibrosis might be related to the lung injury and excessive lung fibroproliferation at the early stage during ICU admission.
dc.language.isoEN
dc.publisherFrontiers Media S.A.
dc.subject.lccMicrobiology
dc.titleLong-term outcomes of survivors with influenza A H1N1 virus-induced severe pneumonia and ARDS: a single-center prospective cohort study
dc.typeArticle
dc.description.keywordsinfluenza A (H1N1) virus
dc.description.keywordssevere community-acquired pneumonia (SCAP)
dc.description.keywordsacute respiratory distress syndrome (ARDS)
dc.description.keywordspulmonary fibrosis
dc.description.keywordspulmonary function
dc.description.doi10.3389/fcimb.2024.1378379
dc.title.journalFrontiers in Cellular and Infection Microbiology
dc.identifier.e-issn2235-2988
dc.identifier.oaioai:doaj.org/journal:90492af2776141bc84544f00ea41b00f


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