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Immunological Responses to Seoul Orthohantavirus in Experimentally and Naturally Infected Brown Rats (<i>Rattus norvegicus</i>)

dc.contributor.authorShumpei P. Yasuda
dc.contributor.authorKenta Shimizu
dc.contributor.authorTakaaki Koma
dc.contributor.authorNguyen Thuy Hoa
dc.contributor.authorMai Quynh Le
dc.contributor.authorZhuoxing Wei
dc.contributor.authorDevinda S. Muthusinghe
dc.contributor.authorSithumini M. W. Lokupathirage
dc.contributor.authorFutoshi Hasebe
dc.contributor.authorTetsu Yamashiro
dc.contributor.authorJiro Arikawa
dc.contributor.authorKumiko Yoshimatsu
dc.contributor.otherDepartment of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo 060-8638, Japan
dc.contributor.otherDepartment of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo 060-8638, Japan
dc.contributor.otherGraduate School of Medicine, Hokkaido University, Sapporo 060-8638, Japan
dc.contributor.otherNational Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam
dc.contributor.otherNational Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam
dc.contributor.otherGraduate School of Infectious Diseases, Hokkaido University, Sapporo 060-0818, Japan
dc.contributor.otherGraduate School of Infectious Diseases, Hokkaido University, Sapporo 060-0818, Japan
dc.contributor.otherGraduate School of Infectious Diseases, Hokkaido University, Sapporo 060-0818, Japan
dc.contributor.otherInstitute of Tropical Medicine, Nagasaki University, Nagasaki 852-8523, Japan
dc.contributor.otherDepartment of Bacteriology, Graduate School of Medicine, University of the Ryukyus, Okinawa 903-0213, Japan
dc.contributor.otherDepartment of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo 060-8638, Japan
dc.contributor.otherDepartment of Microbiology and Immunology, Faculty of Medicine, Hokkaido University, Sapporo 060-8638, Japan
dc.date.accessioned2025-10-09T05:33:28Z
dc.date.available2025-10-09T05:33:28Z
dc.date.issued01-04-2021
dc.identifier.urihttps://www.mdpi.com/1999-4915/13/4/665
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/41165
dc.description.abstractTo clarify the mechanism of Seoul orthohantavirus (SEOV) persistence, we compared the humoral and cell-mediated immune responses to SEOV in experimentally and naturally infected brown rats. Rats that were experimentally infected by the intraperitoneal route showed transient immunoglobulin M (IgM) production, followed by an increased anti-SEOV immunoglobulin G (IgG) antibody response and maturation of IgG avidity. The level of SEOV-specific cytotoxic T lymphocytes (CTLs) peaked at 6 days after inoculation and the viral genome disappeared from serum. In contrast, naturally infected brown rats simultaneously had a high rate of SEOV-specific IgM and IgG antibodies (28/43). Most of the IgM-positive rats (24/27) had the SEOV genome in their lungs, suggesting that chronic SEOV infection was established in those rats. In female rats with IgG avidity maturation, the viral load in the lungs was decreased. On the other hand, there was no relationship between IgG avidity and viral load in the lungs in male rats. A CTL response was not detected in naturally infected rats. The difference between immune responses in the experimentally and naturally infected rats is associated with the establishment of chronic infection in natural hosts.
dc.language.isoEN
dc.publisherMDPI AG
dc.subject.lccMicrobiology
dc.titleImmunological Responses to Seoul Orthohantavirus in Experimentally and Naturally Infected Brown Rats (<i>Rattus norvegicus</i>)
dc.typeArticle
dc.description.keywordshemorrhagic fever with renal syndrome
dc.description.keywordsbunyavirus
dc.description.keywordsIgM
dc.description.keywordsCTLs
dc.description.keywordsreservoir
dc.description.doi10.3390/v13040665
dc.title.journalViruses
dc.identifier.e-issn1999-4915
dc.identifier.oaioai:doaj.org/journal:66c0f7ec438047018c9d2e38028ce7d7
dc.journal.infoVolume 13, Issue 4


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