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Timing dependent neuronal migration is regulated by Cdk5-mediated phosphorylation of JIP1

dc.contributor.authorQinglin Fei
dc.contributor.authorQinglin Fei
dc.contributor.authorQinglin Fei
dc.contributor.authorQinglin Fei
dc.contributor.authorDoo Soon Im
dc.contributor.authorYiwen Xu
dc.contributor.authorTianwen Huang
dc.contributor.authorDianbo Qu
dc.contributor.otherDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
dc.contributor.otherDepartment of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
dc.contributor.otherShanghai Pancreatic Cancer Institute, Shanghai, China
dc.contributor.otherPancreatic Cancer Institute, Fudan University, Shanghai, China
dc.contributor.otherDepartment of Clinical Neurosciences, Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada
dc.contributor.otherFujian Key Laboratory of Vascular Aging, Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, China
dc.contributor.otherFujian Key Laboratory of Vascular Aging, Department of Neurology, Fujian Medical University Union Hospital, Fuzhou, China
dc.contributor.otherDepartment of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada
dc.date.accessioned2025-10-09T05:34:11Z
dc.date.available2025-10-09T05:34:11Z
dc.date.issued01-03-2024
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fcell.2024.1371568/full
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/41180
dc.description.abstractThe mammalian brain, especially the cerebral cortex, has evolved to increase in size and complexity. The proper development of the cerebral cortex requires the coordination of several events, such as differentiation and migration, that are essential for forming a precise six-layered structure. We have previously reported that Cdk5-mediated phosphorylation of JIP1 at T205 modulates axonal out-growth. However, the spatiotemporal expression patterns and functions of these three genes (Cdk5, Cdk5r1 or p35, and Mapk8ip1 or JIP1) in distinct cell types during cortical development remain unclear. In this study, we analyzed single-cell RNA-sequencing data of mouse embryonic cortex and discovered that Cdk5, p35, and JIP1 are dynamically expressed in intermediate progenitors (IPs). Pseudotime analysis revealed that the expression of these three genes was concomitantly upregulated in IPs during neuronal migration and differentiation. By manipulating the expression of JIP1 and phospho-mimetic JIP1 using in utero electroporation, we showed that phosphorylated JIP1 at T205 affected the temporal migration of neurons.
dc.language.isoEN
dc.publisherFrontiers Media S.A.
dc.subject.lccBiology (General)
dc.titleTiming dependent neuronal migration is regulated by Cdk5-mediated phosphorylation of JIP1
dc.typeArticle
dc.description.keywordsneuromigrationneuronal migration
dc.description.keywordsCDK5
dc.description.keywordsJIP1
dc.description.keywordsT205
dc.description.keywordscortical development
dc.description.doi10.3389/fcell.2024.1371568
dc.title.journalFrontiers in Cell and Developmental Biology
dc.identifier.e-issn2296-634X
dc.identifier.oaioai:doaj.org/journal:ced0ebe7e3ab40b291e32e07efcbf133


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