Backround: Disease of HIV-AIDS at Papua more seriouslybecause sufferer total HIV-AIDS from year to year then increasesince year 1979. Augmenting again with society culture Papuacondition with the lowly education level that join in to subsidizerisk disease of HIV-AIDS at Papua. Despitefully there anothertrigger factor likes factor broken home, economy and life style.Government has tried with decide national wisdom ABC orabstinancy, be faithful and condom in order to tackling HIV-AIDSbut until so far not yet show result that have a meaning, evenseveral watchfulness recommend necessary watchfulnessexistences about tackling local model HIV-AIDS at Papua. Thismatter is actually that pushes researcher to look for local modelform in the hook with tackling HIV-AIDS at Papua.Method: This research descriptive method. Location ofresearch at prolific regency Biak Numfor with sample total forsufferer HIV-AIDS as much as 50 person contact AIDS diseases(ODHA) and 50 person not contact AIDS as standards. Customsociety Papua number 200 person represent 7 custom areasPapua with 10 religion figures represents 5 big religions atPapua. Data collecting technique by interview, registration andobservation to get primary data also secondary. Watchfulnessvariable covers free variable that is free sex behaviour, habitdrinks alcoholic drink, drug consumption habit, erudition, attitudeand weak religion teachings practice with negative culturehabit. Bound variable risk disease HIV-AIDS with sub eruditionvariable, attitude and behaviour with moderator variable thatcover economy, life style and broken home. And last liaisonvariable that is disease development HIV-AIDS.Technique and data collecting stage is divided to be 3 stagesthat is: (1) cause factors identification HIV-AIDS, (2) modellocation the testing and (3) model evaluation.Result: At the (time) of problem identification, watchfulnessresult shows that society behaviour factor Papua like free sexbehaviour, decrease it religion value and negative culture habitat prolific has risk towards disease HIV-AIDS. Moderator variablethat is economy/occupation, life style, has influence towardsdisease of HIV-AIDS. Specific local program that can bedeveloped” model H” consist of 2 main concepts, that is:Abstinancy and Be faithful or AB and after done test tries duringapproximately 3 year so model and this program is enougheffective to overcomings risk disease HIV-AIDS at Papua. Testingand first model evaluation is done in ODHA with the statisticstest result descriptively have a meaning with Chi-kuadrat testand McNemar p <0,05 and Cohran’s Q p <0.05 while secondtesting towards society of Papua where descriptively have ameaning with test Willcoxon p <0,05 and Friedman p <0,05.Conclusion: be taken that specific local model that can bedeveloped” H model” and suggested to Government Provinceof Papua and Papua Legislative (DPRP) to make legal fundamentin the form of by law to support this model.Keywords: behaviour, local wisdom AIDS-HIV, disease riskAIDS-HIV