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Novel Physique Index for the Screening of Skeletal Dysplasia at Birth

dc.contributor.authorRyoji Aoki
dc.contributor.authorNobuhiko Nagano
dc.contributor.authorAya Okahashi
dc.contributor.authorShoko Ohashi
dc.contributor.authorYoshinori Fujinaka
dc.contributor.authorItsuro Takigawa
dc.contributor.authorKen Masunaga
dc.contributor.authorIchiro Morioka
dc.contributor.otherDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Oyaguchi-kamimachi, Itabashi-ku, Tokyo 173-8610, Japan
dc.contributor.otherDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Oyaguchi-kamimachi, Itabashi-ku, Tokyo 173-8610, Japan
dc.contributor.otherDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Oyaguchi-kamimachi, Itabashi-ku, Tokyo 173-8610, Japan
dc.contributor.otherDepartment of Neonatology, Tokyo Metropolitan Ohtsuka Hospital, Tokyo 170-8476, Japan
dc.contributor.otherDepartment of Neonatology, Tokyo Metropolitan Ohtsuka Hospital, Tokyo 170-8476, Japan
dc.contributor.otherDepartment of Neonatology, Tokyo Metropolitan Ohtsuka Hospital, Tokyo 170-8476, Japan
dc.contributor.otherDepartment of Neonatology, Tokyo Metropolitan Ohtsuka Hospital, Tokyo 170-8476, Japan
dc.contributor.otherDepartment of Pediatrics and Child Health, Nihon University School of Medicine, Oyaguchi-kamimachi, Itabashi-ku, Tokyo 173-8610, Japan
dc.date.accessioned2021-04-26T00:00:04Z
dc.date.available2025-10-02T03:00:59Z
dc.date.issued01-04-2021
dc.identifier.issn-
dc.identifier.urihttps://www.mdpi.com/2227-9067/8/5/331
dc.description.abstractThis study aimed to devise a novel physique index and investigate its accuracy in identifying newborns with skeletal dysplasia in comparison with head circumference (HC)/height (HT) ratio. The birth weight (W), HT, and HC at birth of 1500 newborns were retrospectively collected. The linear regression equations and coefficients of determination (R<sup>2</sup>) were determined. The formulated equation was corrected by the mean weight for gestational age at birth (Wcorr) as a novel physique index for screening skeletal dysplasia. The index accuracy was assessed using receiver operating characteristic (ROC) curves in 11 newborns by fetal ultrasound and compared with that of the HC/HT ratio. The R<sup>2</sup> values between W and HT, (HT)<sup>2</sup>, and (HT) <sup>3</sup> were 0.978, 0.990, and 0.993, respectively. Those between W and HC, (HC)<sup>2</sup>, and (HC)<sup>3</sup> were 0.974, 0.984, and 0.988, respectively. W/Wcorr × (HC/HT)<sup>3</sup> was used as a novel physique index. Seven newborns had skeletal dysplasia. Our novel physique index had a higher area under the curve (AUC), sensitivity, and specificity than the HC/HT ratio (AUC: 1.00 vs. 0.86, sensitivity: 1.00 vs. 0.86, and specificity: 1.00 vs. 0.75, respectively). Our novel physique index was more accurate than HC/HT ratio and has the potential to accurately identify newborns with skeletal dysplasia.
dc.format-
dc.language.isoEN
dc.publisherMDPI AG
dc.relation.uri['https://revistas.usantotomas.edu.co/index.php/hallazgos/about', 'https://revistas.usantotomas.edu.co/public/journals/12/doc2020/doc_2.PDF', 'https://revistas.usantotomas.edu.co/index.php/hallazgos/']
dc.rightsCC BY-NC-SA
dc.subject['social sciences', 'humanities', 'latin american studies', 'History of scholarship and learning. The humanities', 'AZ20-999', 'Social Sciences', 'H', 'Social sciences (General)', 'H1-99']
dc.subject.lccPediatrics
dc.titleNovel Physique Index for the Screening of Skeletal Dysplasia at Birth
dc.typeArticle
dc.description.keywordsbirth weight
dc.description.keywordshead circumference to height ratio
dc.description.keywordsfemur length
dc.description.keywordsnewborn
dc.description.keywordssmall for gestational age
dc.description.pages-
dc.description.doi10.3390/children8050331
dc.title.journalChildren
dc.identifier.e-issn2227-9067
dc.identifier.oaioai:doaj.org/journal:810c5c37b7404b45ad41950765a57d41
dc.journal.infoVolume 8, Issue 5


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