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Common Patterns and Unique Threats in Antimicrobial Resistance as Demonstrated by Global Gonococcal Surveillance

dc.contributor.authorAdriana Le Van
dc.contributor.authorNazia Rahman
dc.contributor.authorReuel Sandy
dc.contributor.authorNelson Dozier
dc.contributor.authorHunter J. Smith
dc.contributor.authorMelissa J. Martin
dc.contributor.authorKatelyn V. Bartlett
dc.contributor.authorKrit Harncharoenkul
dc.contributor.authorAnna Nanava
dc.contributor.authorTamar Akhvlediani
dc.contributor.authorPaul Rios
dc.contributor.authorSupriya D. Mehta
dc.contributor.authorWalter Agingu
dc.contributor.authorDenis K. Byarugaba
dc.contributor.authorFred Wabwire-Mangen
dc.contributor.authorHannah Kibuuka
dc.contributor.authorBernard Erima
dc.contributor.authorHope O. Kabatasi
dc.contributor.authorNaiki Attram
dc.contributor.authorDutsadee Peerapongpaisarn
dc.contributor.authorWilawan Oransathit
dc.contributor.authorWirote Oransathit
dc.contributor.authorUmaporn Suksawad
dc.contributor.authorWoradee Lurchachaiwong
dc.contributor.authorSomchai Sriplienchan
dc.contributor.authorNonlawat Boonyalai
dc.contributor.authorManeerat Somsri
dc.contributor.authorNithinart Chaitaveep
dc.contributor.authorAnn Jerse
dc.contributor.authorEric Garges
dc.date.accessioned2024-11-12T13:39:44Z
dc.date.available2025-10-02T03:08:43Z
dc.date.issued01-10-2024
dc.identifier.issn-
dc.identifier.urihttps://wwwnc.cdc.gov/eid/article/30/14/24-0296_article
dc.description.abstractThe rapid emergence of antimicrobial-resistant strains of Neisseria gonorrhoeae threatens treatment options and control efforts. The Uniformed Services University Gonococcal Reference Laboratory and Repository of the Global Emerging Infections Surveillance Program receives isolates from several geographically distinct regions worldwide. We analyzed 962 isolates collected during 2014–2022 for genomic and phenotypic antimicrobial resistance. Resistance to antimicrobial drugs previously used for gonococcal infections was high, but of most concern were increases of resistance to currently used antibiotic drugs, such as extended-spectrum cephalosporins and the alternative antibiotic treatment gentamicin. The percentage of isolates with reduced susceptibility to ceftriaxone was 3.6%, to cefixime was 2.5%, and to gentamicin was 15.0%. Although isolates were collected from populations of limited diversity, 706 (73.4%) of isolates demonstrated novel multiantigen sequence types, and 225 (23.4%) had novel multilocus sequence types. Continued surveillance of N. gonorrhoeae is essential to monitoring the prevalence and spread of resistant organisms worldwide.
dc.format-
dc.language.isoEN
dc.publisherCenters for Disease Control and Prevention
dc.relation.uri['https://rmdopen.bmj.com/pages/authors/#waivers_and_discounts', 'https://rmdopen.bmj.com', 'https://rmdopen.bmj.com/pages/about/', 'https://rmdopen.bmj.com/pages/authors/']
dc.rights['CC BY', 'CC BY-NC', 'CC BY-NC-ND']
dc.subject['musculoskeletal disorders', 'rheumatism', 'connective tissue diseases', 'Medicine', 'R']
dc.subject.lccMedicine
dc.titleCommon Patterns and Unique Threats in Antimicrobial Resistance as Demonstrated by Global Gonococcal Surveillance
dc.typeArticle
dc.description.keywordsbacteria
dc.description.keywordssexually transmitted infections
dc.description.keywordsNeisseria gonorrhoeae
dc.description.keywordsgonorrhea
dc.description.keywordssurveillance
dc.description.keywordsantibiotic resistance
dc.description.pages62-70
dc.description.doi10.3201/eid3014.240296
dc.title.journalEmerging Infectious Diseases
dc.identifier.e-issn1080-6059
dc.identifier.oaioai:doaj.org/journal:5a03a2bd1f4542ebaf68717e6cbfe837
dc.journal.infoVolume 30, Issue 14


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