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Essential Oil of <i>Croton zehntneri</i> Prevents Conduction Alterations Produced by Diabetes Mellitus on Vagus Nerve

dc.contributor.authorKerly Shamyra Silva-Alves
dc.contributor.authorFrancisco Walber Ferreira-da-Silva
dc.contributor.authorAndrelina Noronha Coelho-de-Souza
dc.contributor.authorJosé Henrique Leal-Cardoso
dc.contributor.otherLaboratory of Electrophysiology, Superior Institute of Biomedical Science, State University of Ceará, Fortaleza CEP 60.740-000, Brazil
dc.contributor.otherLaboratory of Electrophysiology, Superior Institute of Biomedical Science, State University of Ceará, Fortaleza CEP 60.740-000, Brazil
dc.contributor.otherLaboratory of Electrophysiology, Superior Institute of Biomedical Science, State University of Ceará, Fortaleza CEP 60.740-000, Brazil
dc.contributor.otherLaboratory of Electrophysiology, Superior Institute of Biomedical Science, State University of Ceará, Fortaleza CEP 60.740-000, Brazil
dc.date.accessioned2021-04-29T00:07:25Z
dc.date.available2025-10-02T03:09:22Z
dc.date.issued01-04-2021
dc.identifier.issn-
dc.identifier.urihttps://www.mdpi.com/2223-7747/10/5/893
dc.description.abstractAutonomic diabetic neuropathy (ADN) is a complication of diabetes mellitus (DM), to which there is no specific treatment. In this study, the efficacy of the essential oil of <i>Croton zehntneri</i> (EOCz) in preventing ADN was evaluated in the rat vagus nerve. For the two fastest conducting myelinated types of axons of the vagus nerve, the conduction velocities and rheobase decreased, whilst the duration of the components of the compound action potential of these fibers increased. EOCz completely prevented these DM-induced alterations of the vagus nerve. Unmyelinated fibers were not affected. In conclusion, this investigation demonstrated that EOCz is a potential therapeutic agent for the treatment of ADN.
dc.format-
dc.language.isoEN
dc.publisherMDPI AG
dc.relation.uri['https://www.sciltp.com/journals/mi/aimscope', 'https://www.sciltp.com/journals/mi/', 'https://www.sciltp.com/journals/mi/articleProcessingCharge', 'https://www.sciltp.com/journals/mi/instructionForAuthors']
dc.rightsCC BY
dc.subject['functional materials', 'surfaces', 'interfaces', 'catalysis', 'nanostructured materials', 'membrane materials', 'Materials of engineering and construction. Mechanics of materials', 'TA401-492']
dc.subject.lccBotany
dc.titleEssential Oil of <i>Croton zehntneri</i> Prevents Conduction Alterations Produced by Diabetes Mellitus on Vagus Nerve
dc.typeArticle
dc.description.keywords<i>Croton zehntneri</i>
dc.description.keywordsessential oil
dc.description.keywordsautonomic diabetic neuropathy
dc.description.keywordsvagus nerve
dc.description.keywordscompound action potential
dc.description.pages-
dc.description.doi10.3390/plants10050893
dc.title.journalPlants
dc.identifier.e-issn2223-7747
dc.identifier.oaioai:doaj.org/journal:76b010fd89c747f589b2fa00c7e3181f
dc.journal.infoVolume 10, Issue 5


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