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Detection of <i>Pneumocystis jirovecii</i> in Hospitalized Children Less Than 3 Years of Age

dc.contributor.authorEstelle Menu
dc.contributor.authorJean-Sélim Driouich
dc.contributor.authorLéa Luciani
dc.contributor.authorAurélie Morand
dc.contributor.authorStéphane Ranque
dc.contributor.authorCoralie L’Ollivier
dc.contributor.otherLaboratoire de Parasitologie-Mycologie, IHU Méditerranée Infection, 13385 Marseille, France
dc.contributor.otherLaboratoire de Parasitologie-Mycologie, IHU Méditerranée Infection, 13385 Marseille, France
dc.contributor.otherUnité des Virus Emergents (UVE), Aix Marseille Université, IRD 190, INSERM 1207, IHU-Méditerranée Infection, 13385 Marseille, France
dc.contributor.otherInstitut de Recherche pour le Développement IRD, Aix-Marseille Université, Assistance Publique-Hôpitaux de Marseille, AP-HM, MEPHI: Microbes, Evolution, Phylogénie et Infection, IHU-Méditerranée-Infection, 13385 Marseille, France
dc.contributor.otherLaboratoire de Parasitologie-Mycologie, IHU Méditerranée Infection, 13385 Marseille, France
dc.contributor.otherLaboratoire de Parasitologie-Mycologie, IHU Méditerranée Infection, 13385 Marseille, France
dc.date.accessioned2021-07-23T14:49:10Z
dc.date.available2025-10-02T03:22:21Z
dc.date.issued01-07-2021
dc.identifier.issn-
dc.identifier.urihttps://www.mdpi.com/2309-608X/7/7/546
dc.description.abstractFew data are available in the literature regarding <i>Pneumocystis jirovecii</i> infection in children under 3 years old. This retrospective cohort study aimed to describe medically relevant information among them. All children under 3 years old treated in the same medical units from April 2014 to August 2020 and in whom a <i>P. jirovecii</i> evaluation was undertaken were enrolled in the study. A positive case was defined as a child presenting at least one positive PCR for <i>P. jirovecii</i> in a respiratory sample. Medically relevant information such as demographical characteristics, clinical presentation, microbiological co-infections, and treatments were collected. The objectives were to describe the characteristics of these children with <i>P. jirovecii</i> colonization/infection to determine the key underlying diseases and risk factors, and to identify viral respiratory pathogens associated. The PCR was positive for <i>P. jirovecii</i> in 32 children. Cardiopulmonary pathologies (21.9%) were the most common underlying disease in them, followed by severe combined immunodeficiency (SCID) (18.8%), hyaline membrane disease (15.6%), asthma (9.4%) and acute leukaemia (6.3%). All SCID children were diagnosed with <i>pneumocystis</i> pneumonia. Co-infection with Pj/Rhinovirus (34.4%) was not significant. Overall mortality was 18.8%. Paediatric <i>pneumocystis</i> is not restricted to patients with HIV or SCID and should be considered in pneumonia in children under 3 years old.
dc.format-
dc.language.isoEN
dc.publisherMDPI AG
dc.relation.uri['https://journal.unnes.ac.id/journals/beaj/about#focusandScope', 'https://journal.unnes.ac.id/journals/beaj/about#authorGuidelines', 'https://journal.unnes.ac.id/journals/beaj']
dc.rightsCC BY
dc.subject['economics', 'Economics as a science', 'HB71-74']
dc.subject.lccBiology (General)
dc.titleDetection of <i>Pneumocystis jirovecii</i> in Hospitalized Children Less Than 3 Years of Age
dc.typeArticle
dc.description.keywords<i>Pneumocystis jirovecii</i>
dc.description.keywordsinfants
dc.description.keywordsco-infection
dc.description.keywordsrisk factor
dc.description.pages-
dc.description.doi10.3390/jof7070546
dc.title.journalJournal of Fungi
dc.identifier.e-issn2309-608X
dc.identifier.oaioai:doaj.org/journal:db5fda24ac9e41e88e626d95fe45d90a
dc.journal.infoVolume 7, Issue 7


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