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Antioxidant Effects of Stereoisomers of N-Acetylcysteine (NAC), L-NAC and D-NAC, on Angiotensin II-Stimulated MAP Kinase Activation and Vascular Smooth Muscle Cell Proliferation

dc.contributor.authorMoe Kyaw
dc.contributor.authorMasanori Yoshizumi
dc.contributor.authorKoichiro Tsuchiya
dc.contributor.authorYuki Izawa
dc.contributor.authorYasuhisa Kanematsu
dc.contributor.authorYoshiko Fujita
dc.contributor.authorNermin Ali
dc.contributor.authorKeisuke Ishizawa
dc.contributor.authorAiko Yamauchi
dc.contributor.authorToshiaki Tamaki
dc.contributor.otherDepartment of Pharmacology, The University of Tokushima Graduate School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan
dc.contributor.otherDepartment of Pharmacology, The University of Tokushima Graduate School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan
dc.contributor.otherDepartments of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78 Sho-machi, Tokushima 770-8505, Japan
dc.contributor.otherDepartment of Pharmacology, The University of Tokushima Graduate School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan
dc.contributor.otherDepartment of Pharmacology, The University of Tokushima Graduate School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan
dc.contributor.otherDepartment of Pharmacology, The University of Tokushima Graduate School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan
dc.contributor.otherDepartment of Pharmacology, The University of Tokushima Graduate School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan
dc.contributor.otherDepartment of Pharmacology, The University of Tokushima Graduate School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan
dc.contributor.otherDepartments of Pharmaceutical Information Science, Graduate School of Pharmaceutical Sciences, The University of Tokushima, 1-78 Sho-machi, Tokushima 770-8505, Japan
dc.contributor.otherDepartment of Pharmacology, The University of Tokushima Graduate School of Medicine, 3-18-15 Kuramoto, Tokushima 770-8503, Japan; Corresponding author. FAX: +81-88-633-7062 E-mail: tamaki@basic.med.tokushima-u.ac.jp
dc.date.accessioned2019-07-17T02:02:04Z
dc.date.available2025-10-02T03:39:37Z
dc.date.issued01-01-2004
dc.identifier.issn-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S1347861319323990
dc.description.abstractWe examined the effects of the stereoisomers of N-acetylcysteine (NAC), L-NAC and D-NAC, on cellular glutathione (GSH) concentration and whether NAC-regulated cellular GSH levels are directly associated with angiotensin II (Ang II)-induced intracellular signaling events in vascular smooth muscle cells (VSMC). Both L-NAC and D-NAC similarly increased intracellular GSH concentration. We found that L-NAC and D-NAC both inhibited Ang II-induced c-Jun N-terminal kinase and p38 mitogen-activated protein kinase activation and [3H]-thymidine incorporation in VSMC. Our present study indicates the comparable effects of NAC stereoisomers in regulating intracellular GSH and the redox-dependent intracellular signaling mechanisms in VSMC. Keywords:: N-acetylcysteine, glutathione, vascular smooth muscle cell
dc.format-
dc.language.isoEN
dc.publisherElsevier
dc.relation.uri['https://www.annsaudimed.net/', 'https://www.annsaudimed.net/index.php/resource_center.html', 'https://www.annsaudimed.net/index.php/about_journal.html']
dc.rightsCC BY-NC-ND
dc.subject['medical specialties', 'surgery', 'gynecology', 'obstetrics', 'pediatrics', 'Medicine', 'R']
dc.subject.lccTherapeutics. Pharmacology
dc.titleAntioxidant Effects of Stereoisomers of N-Acetylcysteine (NAC), L-NAC and D-NAC, on Angiotensin II-Stimulated MAP Kinase Activation and Vascular Smooth Muscle Cell Proliferation
dc.typeArticle
dc.description.pages483-486
dc.description.doi10.1254/jphs.sc0040061
dc.title.journalJournal of Pharmacological Sciences
dc.identifier.e-issn-
dc.identifier.oaioai:doaj.org/journal:1850ec7a3e8341f68d41312b74bd76d0
dc.journal.infoVolume 95, Issue 4


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