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Obesity Drives an Oral Microbiota Signature of Female Patients with Periodontitis: A Pilot Study

dc.contributor.authorCharlotte Thomas
dc.contributor.authorMatthieu Minty
dc.contributor.authorThibault Canceill
dc.contributor.authorPascale Loubières
dc.contributor.authorVincent Azalbert
dc.contributor.authorFrançois Tercé
dc.contributor.authorCamille Champion
dc.contributor.authorRémy Burcelin
dc.contributor.authorPierre Barthet
dc.contributor.authorSara Laurencin-Dalicieux
dc.contributor.authorVincent Blasco-Baque
dc.contributor.otherINSERM UMR 1297 Inserm, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Avenue Jean Poulhès 1, CEDEX 4, 31432 Toulouse, France
dc.contributor.otherINSERM UMR 1297 Inserm, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Avenue Jean Poulhès 1, CEDEX 4, 31432 Toulouse, France
dc.contributor.otherFaculté de Chirurgie Dentaire, Université Paul Sabatier III (UPS), 118 Route de Narbonne, CEDEX 9, 31062 Toulouse, France
dc.contributor.otherINSERM UMR 1297 Inserm, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Avenue Jean Poulhès 1, CEDEX 4, 31432 Toulouse, France
dc.contributor.otherINSERM UMR 1297 Inserm, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Avenue Jean Poulhès 1, CEDEX 4, 31432 Toulouse, France
dc.contributor.otherINSERM UMR 1297 Inserm, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Avenue Jean Poulhès 1, CEDEX 4, 31432 Toulouse, France
dc.contributor.otherINSERM UMR 1297 Inserm, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Avenue Jean Poulhès 1, CEDEX 4, 31432 Toulouse, France
dc.contributor.otherINSERM UMR 1297 Inserm, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Avenue Jean Poulhès 1, CEDEX 4, 31432 Toulouse, France
dc.contributor.otherFaculté de Chirurgie Dentaire, Université Paul Sabatier III (UPS), 118 Route de Narbonne, CEDEX 9, 31062 Toulouse, France
dc.contributor.otherFaculté de Chirurgie Dentaire, Université Paul Sabatier III (UPS), 118 Route de Narbonne, CEDEX 9, 31062 Toulouse, France
dc.contributor.otherINSERM UMR 1297 Inserm, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Avenue Jean Poulhès 1, CEDEX 4, 31432 Toulouse, France
dc.date.accessioned2021-04-22T00:07:38Z
dc.date.available2025-10-02T03:43:51Z
dc.date.issued01-04-2021
dc.identifier.issn-
dc.identifier.urihttps://www.mdpi.com/2075-4418/11/5/745
dc.description.abstractThe aim of this study was to analyze the link between oral microbiota and obesity in humans. We conducted a pilot study including 19 subjects with periodontitis divided into two groups: normo-weighted subjects (NWS) with a body mass index (BMI) between 20 and 25 (<i>n</i> = 9) and obese subjects (OS) with a BMI > 30 (<i>n</i> = 10). Obesity was associated with a poor oral health status characterized by an increased number of missing teeth and a higher score of periodontal-support loss associated with dysbiotic oral microbiota (39.45 ± 3.74 vs. 26.41 ± 11.21, <i>p</i> = 0.03 for the Chao 1 index). Oral microbiota taxonomic analysis showed that the abundance of the <i>Capnocytophaga</i> genus was higher (2.47% ± 3.02 vs. 0.27% ± 0.29, <i>p</i> = 0.04) in OS compared to NWS. Obese females (OF) were characterized by an increase in the <i>Streptococcus</i> genus (34.12% ± 14.29 vs. 10.55% ± 10.42, <i>p</i> = 0.05) compared to obese males (OM), where the <i>Neisseria</i> genus was increased (5.75% ± 5.03 vs. 58.05% ± 30.64, <i>p</i> = 0.008). These first data suggest that sex/gender is determinant in the link between oral dysbiotic microbiota and obesity in patients with periodontitis. Our results could lead to recommendations concerning therapeutic strategies for obese patients with periodontitis following the sex/gender.
dc.format-
dc.language.isoEN
dc.publisherMDPI AG
dc.relation.uri['https://journal.ait.edu.az/daj/aim-scope', 'https://journal.ait.edu.az/daj/index', 'https://journal.ait.edu.az/daj/about/submissions']
dc.rightsCC BY-NC
dc.subject['religion', 'religious studies', 'sociology of religion', 'psychology of religion', 'history of religions', 'philosophy of religion', 'Religion (General)', 'BL1-50', 'Philosophy of religion. Psychology of religion. Religion in relation to other subjects', 'BL51-65', 'History and principles of religions', 'BL660-2680', 'Religions of the world', 'BL74-99']
dc.subject.lccMedicine (General)
dc.titleObesity Drives an Oral Microbiota Signature of Female Patients with Periodontitis: A Pilot Study
dc.typeArticle
dc.description.keywordsoral microbiota
dc.description.keywordsobesity
dc.description.keywordsperiodontitis
dc.description.keywordsdysbiosis
dc.description.keywordssex/gender
dc.description.pages-
dc.description.doi10.3390/diagnostics11050745
dc.title.journalDiagnostics
dc.identifier.e-issn2075-4418
dc.identifier.oaioai:doaj.org/journal:582b6cea75a641fda10c83254da38f48
dc.journal.infoVolume 11, Issue 5


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