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Enhanced Biological Activity of a Novel Preparation of <i>Lavandula angustifolia</i> Essential Oil

dc.contributor.authorMałgorzata Miastkowska
dc.contributor.authorTomasz Kantyka
dc.contributor.authorEwa Bielecka
dc.contributor.authorUrszula Kałucka
dc.contributor.authorMarta Kamińska
dc.contributor.authorMałgorzata Kucharska
dc.contributor.authorAnna Kilanowicz
dc.contributor.authorDariusz Cudzik
dc.contributor.authorKrzysztof Cudzik
dc.contributor.otherDepartment of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, 31-155 Cracow, Poland
dc.contributor.otherMalopolska Centre of Biotechnology, Jagiellonian University, 30-387 Kraków, Poland
dc.contributor.otherMalopolska Centre of Biotechnology, Jagiellonian University, 30-387 Kraków, Poland
dc.contributor.otherMalopolska Centre of Biotechnology, Jagiellonian University, 30-387 Kraków, Poland
dc.contributor.otherMalopolska Centre of Biotechnology, Jagiellonian University, 30-387 Kraków, Poland
dc.contributor.otherDepartment of Toxicology, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland
dc.contributor.otherDepartment of Toxicology, Faculty of Pharmacy, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland
dc.contributor.otherOstrowieckie Centrum Medyczne Civil Partnership Anna Olech-Cudzik, Krzysztof Cudzik Iłżecka 31A, 27-400 Ostrowiec Świętokrzyski, Poland
dc.contributor.otherOstrowieckie Centrum Medyczne Civil Partnership Anna Olech-Cudzik, Krzysztof Cudzik Iłżecka 31A, 27-400 Ostrowiec Świętokrzyski, Poland
dc.date.accessioned2021-04-24T00:01:37Z
dc.date.available2025-10-02T03:44:15Z
dc.date.issued01-04-2021
dc.identifier.issn-
dc.identifier.urihttps://www.mdpi.com/1420-3049/26/9/2458
dc.description.abstract<i>Lavandula angustifolia</i>, one of the most popular medicinal plants, is the source of a bioactive essential oil characterized by a wide spectrum of biological activity, e.g., antiseptic, analgesic, and anticancer effects. In dermatology, the oil helps to relieve skin inflammation and exhibit wound healing potential. However, the mechanism of action of the lavender oil depends on its composition, which in turn is dependent on the origin and growing conditions. Our study aimed to compare the composition and proregenerative properties of the commercially-available narrow-leaved lavender oil produced in Provence, France, with the oil obtained from the narrow-leaved lavender cultivated locally in Poland. GC/MS analysis showed that self-manufactured essential oil had lower linalool content than commercial oil (23.2 vs. 40.2%), comparable linalyl acetate content (40.6 vs. 44%), while the proportion of lavandulyl acetate was significantly higher (23.2 vs. 5.5%). To determine the influence of lavender oil on the production of proinflammatory cytokines and proregenerative growth factors, gene expression of the selected signaling molecules by HaCaT cells was investigated using real-time PCR. Results showed a concentration-dependent effect of lavender oils on the production of IL-6, IL-8, and VEGF by the keratinocyte cell line. Finally, the potential of the lavender oil to increase the production of VEGF, the most important angiogenic factor, with the in-house preparation performing significantly better in the in vitro cell models was identified.
dc.format-
dc.language.isoEN
dc.publisherMDPI AG
dc.relation.uri['http://revistes.ub.edu/index.php/AFEL/about/submissions#authorGuidelines', 'https://revistes.ub.edu/index.php/AFEL/about', 'http://revistes.ub.edu/index.php/AFEL/index']
dc.rightsCC BY
dc.subject['linguistics', 'Language and Literature', 'P']
dc.subject.lccOrganic chemistry
dc.titleEnhanced Biological Activity of a Novel Preparation of <i>Lavandula angustifolia</i> Essential Oil
dc.typeArticle
dc.description.keywords<i>Lavandula angustifolia</i> essential oil
dc.description.keywordsGC/MS analysis
dc.description.keywordswound healing
dc.description.keywordsproinflammatory cytokines
dc.description.keywordsproregenerative growth factors
dc.description.keywordsHaCaT
dc.description.pages-
dc.description.doi10.3390/molecules26092458
dc.title.journalMolecules
dc.identifier.e-issn1420-3049
dc.identifier.oaioai:doaj.org/journal:3074326310e1499b813d87ca8b85cafa
dc.journal.infoVolume 26, Issue 9


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