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Association of metabolic score for insulin resistance with progression or regression of prediabetes: evidence from a multicenter Chinese medical examination cohort study

dc.contributor.authorGuotai Sheng
dc.contributor.authorMaobin Kuang
dc.contributor.authorMaobin Kuang
dc.contributor.authorRuijuan Yang
dc.contributor.authorRuijuan Yang
dc.contributor.authorYang Zou
dc.contributor.otherJiangxi Provincial Geriatric Hospital, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China
dc.contributor.otherJiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China
dc.contributor.otherJiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China
dc.contributor.otherJiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China
dc.contributor.otherDepartment of Endocrinology, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China
dc.contributor.otherJiangxi Cardiovascular Research Institute, Jiangxi Provincial People’s Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, China
dc.date.accessioned2024-11-11T04:38:31Z
dc.date.available2025-10-02T03:45:11Z
dc.date.issued01-11-2024
dc.identifier.issn-
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fendo.2024.1388751/full
dc.description.abstractObjectiveFew studies have evaluated the changes in blood glucose status in individuals with prediabetes, and this study aimed to analyze the association between metabolic score for insulin resistance (MetS-IR) and the progression or regression of prediabetes.MethodsThis retrospective cohort study used research data from medical examination institutions under the Rich Healthcare Group in 32 regions across 11 cities in China. Progression of prediabetes to diabetes and regression to normal fasting glucose (NFG) were defined based on glycemic changes during follow-up. The association between MetS-IR and the progression or regression of prediabetes was analyzed using multivariate Cox regression, restricted cubic splines, and piecewise regression models.ResultsData from 15,421 prediabetic subjects were analyzed. Over an average follow-up of 2.96 years, 6,481 individuals (42.03%) returned to NFG, and 2,424 (15.72%) progressed to diabetes. After controlling for confounding factors, an increase in MetS-IR was observed to increase the risk of diabetes onset in the prediabetic population, whereas a decrease in MetS-IR had a protective effect for returning to NFG. Additionally, a nonlinear relationship between MetS-IR and prediabetes regression was observed, with 37.22 identified as the inflection point; prediabetes regression rates were significantly higher before this point and markedly decreased after it.ConclusionFor individuals with prediabetes, an increase in MetS-IR may lead to an increased risk of diabetes; conversely, a decrease in MetS-IR enhances the protective effect for returning to NFG and keeping MetS-IR below 37.22 is significant for the regression of prediabetes.
dc.format-
dc.language.isoEN
dc.publisherFrontiers Media S.A.
dc.relation.uri['https://ejournal.upnvj.ac.id/jded/as', 'https://ejournal.upnvj.ac.id/jded/AUTHOR', 'https://ejournal.upnvj.ac.id/index.php/jded/index']
dc.rightsCC BY
dc.subject['development', 'economics', 'digitalization', 'industrial economics', 'regional economics', 'environment', 'Economics as a science', 'HB71-74']
dc.subject.lccDiseases of the endocrine glands. Clinical endocrinology
dc.titleAssociation of metabolic score for insulin resistance with progression or regression of prediabetes: evidence from a multicenter Chinese medical examination cohort study
dc.typeArticle
dc.description.keywordsdiabetes
dc.description.keywordsmetabolic score for insulin resistance
dc.description.keywordsprogression of prediabetes
dc.description.keywordsregression of prediabetes
dc.description.keywordsChinese
dc.description.pages-
dc.description.doi10.3389/fendo.2024.1388751
dc.title.journalFrontiers in Endocrinology
dc.identifier.e-issn1664-2392
dc.identifier.oaioai:doaj.org/journal:cd134b161f64454ea4619b5dc6342a2e
dc.journal.info-


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