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Advanced glycosylated end products restrain the osteogenic differentiation of the periodontal ligament stem cell

dc.contributor.authorZhu-Ling Guo
dc.contributor.authorShan-Ling Gan
dc.contributor.authorChun-Yi Cao
dc.contributor.authorRao Fu
dc.contributor.authorSheng-Ping Cao
dc.contributor.authorChen Xie
dc.contributor.authorJing-Wei Chen
dc.contributor.authorAlex Gibson
dc.contributor.authorXu Zheng
dc.contributor.authorNai-chia Teng
dc.contributor.otherSchool of Dentistry, Hainan Medical University, Hainan, PR China; Department of Dentistry, The First Affiliated Hospital of Hainan Medical University, Hainan, PR China
dc.contributor.otherSchool of Dentistry, Hainan Medical University, Hainan, PR China
dc.contributor.otherSchool of Dentistry, Hainan Medical University, Hainan, PR China
dc.contributor.otherSchool of Dentistry, Hainan Medical University, Hainan, PR China
dc.contributor.otherSchool of Dentistry, Hainan Medical University, Hainan, PR China
dc.contributor.otherSchool of Dentistry, Hainan Medical University, Hainan, PR China
dc.contributor.otherSchool of Dentistry, Hainan Medical University, Hainan, PR China
dc.contributor.otherSchool of Dentistry, Hainan Medical University, Hainan, PR China
dc.contributor.otherSchool of Dentistry, Hainan Medical University, Hainan, PR China; Department of Dentistry, The First Affiliated Hospital of Hainan Medical University, Hainan, PR China; Corresponding author. School of Dentistry, Hainan Medical University, Hainan, PR China. Fax: +086089866984599.
dc.contributor.otherSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taiwan; Department of Dentistry, Taipei Medical University Hospital, Taiwan; Corresponding author. School of Dentistry, College of Oral Medicine, Taipei Medical University, Taiwan. Fax: +886227362295.
dc.date.accessioned2019-06-05T05:48:29Z
dc.date.available2025-10-02T03:46:43Z
dc.date.issued01-06-2019
dc.identifier.issn-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S1991790219301709
dc.description.abstractBackground/purpose: Many studies have confirmed that periodontal disease interacts with diabetes. The aim of this study was to examine whether the advanced glycosylated end products (AGEs), which are generated by diabetics, have important effects on the osteogenic differentiation of periodontal ligament stem cells (PDLSCs). Materials and methods: In this study PDLSCs were isolated from the periodontal ligaments of extracted third molar teeth. The subjects were divided into two groups, which included the normal control group (N-PDLSCs) and the AGEs-stimulating group (A-PDLSCs). Changes of receptor of AGEs (RAGE) and cumulative ROS in PDLSCs were monitored by western blot and flow cytometry, respectively. Results: In the study AGEs noticeably inhibited the osteogenic differentiation of PDLSCs, with significant lower calcification nodules detected in A-PDLSCs (P < 0.01). RAGE expression level and ROS accumulation in A-PDLSCs were clearly higher than those in N-PDLSCs (P < 0.01). Conclusion: Our conclusions were that AGEs may cause the apoptosis of stem cells, which could lead to the disorder of bone differentiation function of PDLSCs. Keywords: AGEs (advanced glycosylated end products), PDLSCs (periodontal ligament stem cells), Periodontal disease, Diabetes mellitus, Prevention
dc.format-
dc.language.isoEN
dc.publisherElsevier
dc.relation.uri['http://www.raco.cat/index.php/Aurora/index', 'http://www.raco.cat/index.php/Aurora/about/submissions#authorGuidelines', 'https://raco.cat/index.php/Aurora/about']
dc.rightsCC BY
dc.subject['philosophy', 'poetry', 'exile', 'Language and Literature', 'P', 'Philosophy. Psychology. Religion', 'B']
dc.subject.lccDentistry
dc.titleAdvanced glycosylated end products restrain the osteogenic differentiation of the periodontal ligament stem cell
dc.typeArticle
dc.description.pages146-151
dc.description.doi10.1016/j.jds.2019.03.007
dc.title.journalJournal of Dental Sciences
dc.identifier.e-issn-
dc.identifier.oaioai:doaj.org/journal:18948426aba142438d4f145182bf25aa
dc.journal.infoVolume 14, Issue 2


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