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Hypervirulent <i>Klebsiella pneumoniae</i> Endogenous Endophthalmitis—A Global Emerging Disease

dc.contributor.authorDragos Serban
dc.contributor.authorAlina Popa Cherecheanu
dc.contributor.authorAna Maria Dascalu
dc.contributor.authorBogdan Socea
dc.contributor.authorGeta Vancea
dc.contributor.authorDaniela Stana
dc.contributor.authorGabriel Catalin Smarandache
dc.contributor.authorAlexandru Dan Sabau
dc.contributor.authorDaniel Ovidiu Costea
dc.contributor.otherFaculty of Medicine, “Carol Davila” University of Medicine and Pharmacy Bucharest, 020011 Bucharest, Romania
dc.contributor.otherFaculty of Medicine, “Carol Davila” University of Medicine and Pharmacy Bucharest, 020011 Bucharest, Romania
dc.contributor.otherFaculty of Medicine, “Carol Davila” University of Medicine and Pharmacy Bucharest, 020011 Bucharest, Romania
dc.contributor.otherFaculty of Medicine, “Carol Davila” University of Medicine and Pharmacy Bucharest, 020011 Bucharest, Romania
dc.contributor.otherFaculty of Medicine, “Carol Davila” University of Medicine and Pharmacy Bucharest, 020011 Bucharest, Romania
dc.contributor.otherDepartment of Ophthalmology, University Emergency Hospital Bucharest, 050098 Bucharest, Romania
dc.contributor.otherFaculty of Medicine, “Carol Davila” University of Medicine and Pharmacy Bucharest, 020011 Bucharest, Romania
dc.contributor.other3rd Clinical Department, Faculty of Medicine, “Lucian Blaga” University Sibiu, 550024 Sibiu, Romania
dc.contributor.other3rd Clinical Department, Faculty of Medicine, “Lucian Blaga” University Sibiu, 550024 Sibiu, Romania
dc.date.accessioned2021-07-23T14:50:37Z
dc.date.available2025-10-02T03:46:55Z
dc.date.issued01-07-2021
dc.identifier.issn-
dc.identifier.urihttps://www.mdpi.com/2075-1729/11/7/676
dc.description.abstractThe review aims to document the new emerging hypervirulent <i>Klebsiella pneumoniae</i> (Kp) endogenous endophthalmitis (EKE) in terms of incidence, microbiological characterization of the pathogenic agent, associated risk factors, management, and outcomes. Hypervirulent (hv) strains of KP (hvKp) induce invasive liver abscesses (LA) with specific clinical features. Up to 80–90% of cases have hepatic liver abscess as a primary focus of infection, followed by renal or lung hvKp infections. However, the incidence of EKE in patients with KPLA varied between 3.4% (19) and 12.6% (13), with a total of 95 cases of endophthalmitis in 1455 cases of KPLA (6.5%). Severe visual loss was encountered in 75% of cases, with 25% bilateral involvement. Intravitreal antibiotics are the mainstay therapeutic approach. Pars plana vitrectomy is a subject of controversy. HvKp strains present mostly natural “wild-type” antibiotic resistance profile suggestive for community-acquired infections, being highly susceptive to the third and fourth generation of cephalosporins and carbapenems. Antimicrobial resistance in hypervirulent strains was recently documented via plasmid transfer and may result in extremely difficult to treat cases. Global dissemination of these strains is a major epidemiologic shift that should be considered in the diagnostic and therapeutic management of patients with endogenous endophthalmitis. Ophthalmologic screening in patients with KPLA and other hvKp infections and a multidisciplinary therapeutic approach is extremely important for early diagnosis and preservation of the visual function.
dc.format-
dc.language.isoEN
dc.publisherMDPI AG
dc.relation.uri['http://revistas.uned.es/index.php/ETFVI/about/submissions#authorGuidelines', 'http://revistas.uned.es/index.php/ETFVI', 'http://revistas.uned.es/index.php/ETFVI/about/editorialPolicies#focusAndScope']
dc.rightsCC BY-NC
dc.subject['geography', 'geographical studies', 'spatial planning', 'urban geography', 'Geography. Anthropology. Recreation', 'G', 'Human ecology. Anthropogeography', 'GF1-900', 'Cities. Urban geography', 'GF125', 'Geography (General)', 'G1-922']
dc.subject.lccScience
dc.titleHypervirulent <i>Klebsiella pneumoniae</i> Endogenous Endophthalmitis—A Global Emerging Disease
dc.typeArticle
dc.description.keywordshypervirulent <i>Klebsiella pneumoniae</i>
dc.description.keywordsinvasive liver abscess syndrome
dc.description.keywordspercutaneous drainage
dc.description.keywordsendophthalmitis
dc.description.keywordsearly diagnosis
dc.description.keywordsintravitreal antibiotherapy
dc.description.pages-
dc.description.doi10.3390/life11070676
dc.title.journalLife
dc.identifier.e-issn2075-1729
dc.identifier.oaioai:doaj.org/journal:d0a09724cf7943ef8769dca95e1d7110
dc.journal.infoVolume 11, Issue 7


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