Show simple item record

Toxicokinetics of the plasticizer, N-butylbenzenesulfonamide, in plasma and brain following oral exposure in rodents: Route, species, and sex comparison

dc.contributor.authorSuramya Waidyanatha
dc.contributor.authorSeth Gibbs
dc.contributor.authorNatalie South
dc.contributor.authorJeremy P. Smith
dc.contributor.authorEsra Mutlu
dc.contributor.authorBrian Burback
dc.contributor.authorYu Cao
dc.contributor.authorCynthia V. Rider
dc.contributor.otherDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States; Corresponding author at: Division of the National Toxicology Program National Institutes of Environmental Health Sciences, P.O. Box 12233 Mail Drop K2-07, Research Triangle Park, NC 27709, United States.
dc.contributor.otherBattelle Memorial Institute, Columbus, OH, United States
dc.contributor.otherBattelle Memorial Institute, Columbus, OH, United States
dc.contributor.otherBattelle Memorial Institute, Columbus, OH, United States
dc.contributor.otherDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States
dc.contributor.otherBattelle Memorial Institute, Columbus, OH, United States
dc.contributor.otherBattelle Memorial Institute, Columbus, OH, United States
dc.contributor.otherDivision of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States
dc.date.accessioned2020-06-10T06:43:25Z
dc.date.available2025-10-02T03:47:45Z
dc.date.issued01-01-2020
dc.identifier.issn-
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S2214750020303309
dc.description.abstractN-Butylbenzenesulfonamide (NBBS) is a widely used plasticizer and hence there is potential for human exposure via oral routes. This work investigates the toxicokinetic behavior of NBBS in rodents following a single gavage (20, 60, and 200 mg/kg body weight) or multi-day feed administration (500, 1000, and 2000 ppm). In male and female rats following gavage administration, maximum plasma NBBS concentration, Cmax, was reached at ≤0.539 h. Cmax increased proportionally to the dose. Area under the curve (AUC) increased more than proportionally to the dose and was 4- to 5-fold higher in females than in males. In mice, plasma Cmax was reached at ≤0.136 h and increased proportionally to the dose in female mice and more than proportionally to the dose in males. AUC increased more than proportionally to the dose with no apparent sex difference. Elimination of NBBS in plasma was faster in mice (half-life (h); mice ≤0.432, rat ≤3.55). Oral bioavailability was higher in female rats (≥60%) than males (23-52%) with apparent saturation of clearance at ∼200 mg/kg body weight in females. In mice, bioavailability (5-14%) was lower with no apparent sex difference. NBBS was detected in brains of rats and mice but with low brain:plasma ratios (rats, ≤5; mice, ≤1) suggesting low potential to cross the blood brain barrier. Systemic exposure in male rats and mice following a single gavage administration was ≥48-fold higher than multi-day feed exposure. These data demonstrate potential species, sex, dose- and route-related difference in toxicokinetics of NBBS in rodents.
dc.format-
dc.language.isoEN
dc.publisherElsevier
dc.relation.uri['https://www.journals.elsevier.com/pulmonology/', 'https://www.elsevier.com/journals/pulmonology/2531-0437/guide-for-authors', 'https://www.journals.elsevier.com/pulmonology']
dc.rights['CC BY', 'CC BY-NC-ND']
dc.subject['respiratory system diseases', 'pulmonary medicine', 'lung diseases', 'Diseases of the respiratory system', 'RC705-779']
dc.subject.lccToxicology. Poisons
dc.titleToxicokinetics of the plasticizer, N-butylbenzenesulfonamide, in plasma and brain following oral exposure in rodents: Route, species, and sex comparison
dc.typeArticle
dc.description.keywordsN-butylbenzenesulfonamide
dc.description.keywordsplasticizer
dc.description.keywordssystemic exposure
dc.description.keywordshalf-life
dc.description.keywordsclearance
dc.description.keywordsrodents
dc.description.pages711-722
dc.description.doi10.1016/j.toxrep.2020.05.005
dc.title.journalToxicology Reports
dc.identifier.e-issn-
dc.identifier.oaioai:doaj.org/journal:10e7c595cbb748a2a8c46b89a01946bb
dc.journal.info-


This item appears in the following Collection(s)

Show simple item record