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Preliminary Biological Activity Screening of <i>Plectranthus</i> spp. Extracts for the Search of Anticancer Lead Molecules

dc.contributor.authorEpole Ntungwe
dc.contributor.authorEva María Domínguez-Martín
dc.contributor.authorCatarina Teodósio
dc.contributor.authorSilvia Teixidó-Trujillo
dc.contributor.authorNatalia Armas Capote
dc.contributor.authorLucilia Saraiva
dc.contributor.authorAna María Díaz-Lanza
dc.contributor.authorNoélia Duarte
dc.contributor.authorPatrícia Rijo
dc.contributor.otherCBIOS—Universidade Lusófona Research Center for Biosciences & Health Technologies, Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisboa, Portugal
dc.contributor.otherCBIOS—Universidade Lusófona Research Center for Biosciences & Health Technologies, Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisboa, Portugal
dc.contributor.otherCBIOS—Universidade Lusófona Research Center for Biosciences & Health Technologies, Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisboa, Portugal
dc.contributor.otherCentro Atlántico del Medicamento S.A., Avenida Trinidad 61, 7ª Planta, Torre Agustín Arévalo, 38204 La Laguna, Tenerife, Spain
dc.contributor.otherCentro Atlántico del Medicamento S.A., Avenida Trinidad 61, 7ª Planta, Torre Agustín Arévalo, 38204 La Laguna, Tenerife, Spain
dc.contributor.otherLAQV/REQUIMTE, Laboratório de Microbiologia, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira n.º 228, 4050-313 Porto, Portugal
dc.contributor.otherDepartment of Biomedical Sciences, Faculty of Pharmacy, University of Alcalá de Henares, Ctra. A2, Km 33.100—Campus Universitario, 28805 Alcalá de Henares, Spain
dc.contributor.otherInstituto de Investigação do Medicamento (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, 1649-003 Lisboa, Portugal
dc.contributor.otherCBIOS—Universidade Lusófona Research Center for Biosciences & Health Technologies, Universidade Lusófona de Humanidades e Tecnologias, Campo Grande 376, 1749-024 Lisboa, Portugal
dc.date.accessioned2021-04-24T00:04:36Z
dc.date.available2025-10-02T04:18:08Z
dc.date.issued01-04-2021
dc.identifier.issn-
dc.identifier.urihttps://www.mdpi.com/1424-8247/14/5/402
dc.description.abstract<i>Plectranthus</i> species (Lamiaceae) have been employed in traditional medicine and this is now validated by the presence of bioactive abietane-type diterpenoids. Herein, sixteen <i>Plectranthus</i> acetonic extracts were prepared by ultrasound-assisted extraction and their biological activity was screened. The antimicrobial activity of each extract was screened against yeasts, and Gram-positive and Gram-negative bacteria. The <i>P. hadiensis</i> and <i>P. mutabilis</i> extracts possessed significant activity against <i>Staphylococcus aureus</i> and <i>Candida albicans</i> (microdilution method). Moreover, all extracts showed antioxidant activity using the DPPH method, with <i>P. hadiensis</i> and <i>P. mutabilis</i> extracts having the highest scavenging activities. Selected by the <i>Artemia salina</i> model, <i>P. hadiensis</i> and <i>P.ciliatus</i> possessed low micromolar anti-proliferative activities in human colon, breast, and lung cancer cell lines. Furthermore, the most bioactive extract of <i>P. hadiensis</i> leaves and the known abietane diterpene, 7α-acetoxy-6β-hydroxyroyleanone isolated from this plant, were tested against the aggressive type triple negative breast cancer (MDA-MB-231S). <i>P. hadiensis</i> extract reduced the viability of MDA-MB-231S cancer cell line cells, showing an IC<sub>50</sub> value of 25.6 µg/mL. The IC<sub>50</sub> value of 7α-acetoxy-6β-hydroxyroyleanone was 5.5 µM (2.15 µg/mL), suggesting that this lead molecule is a potential starting tool for the development of anti-cancer drugs.
dc.format-
dc.language.isoEN
dc.publisherMDPI AG
dc.relation.uri['https://www.journals.elsevier.com/applied-computing-and-geosciences', 'https://www.elsevier.com/journals/applied-computing-and-geosciences/2590-1974/guide-for-authors', 'https://www.elsevier.com/authors/open-access/choice#waivers']
dc.rights['CC BY', 'CC BY-NC-ND', 'CC BY-NC']
dc.subject['applied computing', 'geophysics', 'informatics', 'geosciences', 'Geography. Anthropology. Recreation', 'G', 'Geology', 'QE1-996.5', 'Electronic computers. Computer science', 'QA75.5-76.95']
dc.subject.lccMedicine
dc.titlePreliminary Biological Activity Screening of <i>Plectranthus</i> spp. Extracts for the Search of Anticancer Lead Molecules
dc.typeArticle
dc.description.keywords<i>Plectranthus</i>
dc.description.keywordsroyleanone
dc.description.keywords7α-acetoxy-6β-hydroxyroyleanone
dc.description.keywords<i>ent</i>-abietane
dc.description.keywordsantitumoral activity
dc.description.keywordsantimicrobial activity
dc.description.pages-
dc.description.doi10.3390/ph14050402
dc.title.journalPharmaceuticals
dc.identifier.e-issn1424-8247
dc.identifier.oaioai:doaj.org/journal:63b3cd57c15e4da5a5b2b575907e841e
dc.journal.infoVolume 14, Issue 5


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