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Treatment of chronic osteomyelitis with gradient release of DGEA and vancomycin hydrogel-microsphere system and its mechanism

dc.contributor.authorYuhao Zheng
dc.contributor.authorYue Wang
dc.contributor.authorFan Sheng
dc.contributor.authorShu Wang
dc.contributor.authorYing Zhou
dc.contributor.authorXiaoxu Li
dc.contributor.authorNing Li
dc.contributor.authorWenling Song
dc.contributor.authorZhiming Song
dc.contributor.otherDepartment of Sports Medicine, Orthopedics’ Clinic, The First Hospital of Jilin University, Changchun, Jilin, China
dc.contributor.otherDepartment of Sports Medicine, Orthopedics’ Clinic, The First Hospital of Jilin University, Changchun, Jilin, China
dc.contributor.otherDepartment of Dermatology, The Second Hospital of Jilin University, Changchun, Jilin, China
dc.contributor.otherDepartment of Radiotherapy, The Second Hospital of Jilin University, Changchun, Jilin, China
dc.contributor.otherDepartment of Dermatology, The Second Hospital of Jilin University, Changchun, Jilin, China
dc.contributor.otherDepartment of Sports Medicine, Orthopedics’ Clinic, The First Hospital of Jilin University, Changchun, Jilin, China
dc.contributor.otherDepartment of Sports Medicine, Orthopedics’ Clinic, The First Hospital of Jilin University, Changchun, Jilin, China
dc.contributor.otherDepartment of Obstetrics, The First Hospital of Jilin University, Changchun, Jilin, China
dc.contributor.otherDepartment of Sports Medicine, Orthopedics’ Clinic, The First Hospital of Jilin University, Changchun, Jilin, China
dc.date.accessioned2024-11-11T04:38:49Z
dc.date.available2025-10-02T04:19:47Z
dc.date.issued01-11-2024
dc.identifier.issn-
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fphar.2024.1499742/full
dc.description.abstractIn recent years, the treatment of chronic osteomyelitis mediated by biodegradable polymer platforms has received increasing attention. This paper reports an advanced drug delivery system, vancomycin (VA) and DGEA loaded microspheres embedded in injectable thermosensitive polypeptide hydrogels (i.e., hydrogel-microsphere (Gel-MP) construct), for continuous release of drugs with different mechanisms and more comprehensive treatment of chronic osteomyelitis. The Gel-MP construct exhibits continuous biodegradability and excellent biocompatibility. Microspheres (MP) are wrapped inside Gel. With the degradation of Gel, VA and MP are released from them, VA released with faster degradation speed, achieving a potent antibacterial effect and effectively controlling infection. Due to the slower degradation rate of MP compared to Gel, subsequently, DGEA is released from MP to induce bone formation and produce the effect of filling bone defects. Compared with other formulations, the in vivo combinational treatment of Gel/VA-MP/DGEA can simultaneously balance antibacterial and osteogenic effects. More importantly, local sustained-release drug delivery systems can significantly mitigate the systemic toxicity of drugs. Therefore, the injection local sequential drug delivery system has broad prospects in the clinical application of treating chronic osteomyelitis.
dc.format-
dc.language.isoEN
dc.publisherFrontiers Media S.A.
dc.relation.uri['https://www.elsevier.com/journals/slas-discovery/2472-5552/guide-for-authors', 'https://www.journals.elsevier.com/slas-discovery', 'https://www.elsevier.com/authors/open-access/choice#waivers']
dc.rights['CC BY', 'CC BY-NC-ND']
dc.subject['drug discovery sciences', 'biomarker discovery', 'assay development', 'virtual medium- or high-throughput screening', 'lead generation and optimization', 'informatics', 'Medicine (General)', 'R5-920', 'Biotechnology', 'TP248.13-248.65']
dc.subject.lccTherapeutics. Pharmacology
dc.titleTreatment of chronic osteomyelitis with gradient release of DGEA and vancomycin hydrogel-microsphere system and its mechanism
dc.typeArticle
dc.description.keywordsthermo-sensitive hydrogel
dc.description.keywordsmicrosphere
dc.description.keywordssequential drug release
dc.description.keywordsosteomyelitis
dc.description.keywordsdrug delivery
dc.description.pages-
dc.description.doi10.3389/fphar.2024.1499742
dc.title.journalFrontiers in Pharmacology
dc.identifier.e-issn1663-9812
dc.identifier.oaioai:doaj.org/journal:31a39168916e46f584efa9c4bd255931
dc.journal.info-


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