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Heritability of Cardiothoracic Ratio and Aortic Arch Calcification in Twins

dc.contributor.authorZsofia Jokkel
dc.contributor.authorBianka Forgo
dc.contributor.authorChristopher Hani-Gaius Ghattas
dc.contributor.authorMarton Piroska
dc.contributor.authorHelga Szabó
dc.contributor.authorDavid L. Tarnoki
dc.contributor.authorAdam D. Tarnoki
dc.contributor.authorSooji Lee
dc.contributor.authorJoohon Sung
dc.contributor.otherMedical Imaging Centre, Semmelweis University, 78/A Üllői Street, 1082 Budapest, Hungary
dc.contributor.otherDepartment of Radiology, Faculty of Medicine and Health, Örebro University, Fakultetsgatan 1, 702 81 Örebro, Sweden
dc.contributor.otherMedical Imaging Centre, Semmelweis University, 78/A Üllői Street, 1082 Budapest, Hungary
dc.contributor.otherMedical Imaging Centre, Semmelweis University, 78/A Üllői Street, 1082 Budapest, Hungary
dc.contributor.otherMedical Imaging Centre, Semmelweis University, 78/A Üllői Street, 1082 Budapest, Hungary
dc.contributor.otherMedical Imaging Centre, Semmelweis University, 78/A Üllői Street, 1082 Budapest, Hungary
dc.contributor.otherMedical Imaging Centre, Semmelweis University, 78/A Üllői Street, 1082 Budapest, Hungary
dc.contributor.otherGenome and Health Big Data Laboratory, Department of Public Health, Graduate School of Public Health, Seoul National University, 1 Gwanak-ro Gwanak-gu, Seoul 08826, Korea
dc.contributor.otherGenome and Health Big Data Laboratory, Department of Public Health, Graduate School of Public Health, Seoul National University, 1 Gwanak-ro Gwanak-gu, Seoul 08826, Korea
dc.date.accessioned2021-04-28T00:03:00Z
dc.date.available2025-10-02T04:32:48Z
dc.date.issued01-04-2021
dc.identifier.issn-
dc.identifier.urihttps://www.mdpi.com/1648-9144/57/5/421
dc.description.abstract<i>Background and Objectives</i>: Aortic arch calcification (AoAC) is associated with a variety of cardiovascular complications. The measurement and grading of AoAC using posteroanterior (PA) chest X-rays are well established. The cardiothoracic ratio (CTR) can be simultaneously measured with PA chest X-rays and used as an index of cardiomegaly. The genetic and environmental contributions to the degree of the AoAC and CTR are not well understood. The purpose of this study was to investigate the effect of genetics and environmental factors on the AoAC and CTR. <i>Materials and Methods</i>: A total of 684 twins from the South Korean twin registry (261 monozygotic, MZ and 81 dizygotic, DZ pairs; mean age 38.6 ± 7.9 years, male/female = 264/420) underwent PA chest X-rays. Cardiovascular risk factors and anthropometric data were also collected. The AoAC and CTR were measured and graded using a standardized method. A structural equation method was used to calculate the proportion of variance explained by genetic and environmental factors behind AoAC and CTR. <i>Results</i>: The within-pair differences were low regarding the grade of AoAC, with only a few twin pairs showing large intra-pair differences. We found that the thoracic width showed high heritability (0.67, 95% CI: 0.59–0.73, <i>p</i> = 1). Moderate heritability was detected regarding cardiac width (0.54, 95% CI: 0.45–0.62, <i>p</i> = 0.572) and CTR (0.54, 95% CI: 0.44–0.62, <i>p</i> = 0.701). <i>Conclusions</i>: The heritable component was significant regarding thoracic width, cardiac width, and the CTR.
dc.format-
dc.language.isoEN
dc.publisherMDPI AG
dc.relation.uri['https://www.elsevier.com/journals/journal-of-government-and-economics/2667-3193/guide-for-authors', 'https://www.elsevier.com/authors/open-access/choice#waivers', 'https://www.journals.elsevier.com/journal-of-government-and-economics']
dc.rights['CC BY', 'CC BY-NC-ND']
dc.subject['government', 'government incentives', 'economic policy', 'development', 'Economics as a science', 'HB71-74']
dc.subject.lccMedicine (General)
dc.titleHeritability of Cardiothoracic Ratio and Aortic Arch Calcification in Twins
dc.typeArticle
dc.description.keywordstwin study
dc.description.keywordsheritability
dc.description.keywordsaortic calcification
dc.description.keywordscardiothoracic ratio
dc.description.keywordsatherosclerosis
dc.description.pages-
dc.description.doi10.3390/medicina57050421
dc.title.journalMedicina
dc.identifier.e-issn1648-9144
dc.identifier.oaioai:doaj.org/journal:89eca3806d7343f2938967daef004c42
dc.journal.infoVolume 57, Issue 5


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