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Molecular Characterization of Noroviruses Causing Acute Gastroenteritis Outbreaks among US Military Recruits, 2013–2023

dc.contributor.authorMelissa S. Anderson
dc.contributor.authorChanel A. Mosby-Tourtellot
dc.contributor.authorRegina Z. Cer
dc.contributor.authorDaniel J. Crouch
dc.contributor.authorRyan S. Underwood
dc.contributor.authorCailin S. La Claire
dc.contributor.authorRoger W. Pan
dc.contributor.authorEvelyn W. Mahugu
dc.contributor.authorHunter J. Smith
dc.contributor.authorKimberly A. Bishop-Lilly
dc.contributor.authorMathew D. Esona
dc.contributor.authorFrancisco Mimica Porras
dc.contributor.authorMichelle Hartman-Lane
dc.date.accessioned2024-11-12T13:39:45Z
dc.date.available2025-10-02T04:59:36Z
dc.date.issued01-10-2024
dc.identifier.issn-
dc.identifier.urihttps://wwwnc.cdc.gov/eid/article/30/14/24-0307_article
dc.description.abstractNorovirus is the leading cause of acute gastroenteritis (AGE) worldwide. Norovirus outbreaks at military facilities can cause loss of training and working days and increased healthcare utilization, affecting force readiness. During 2013–2023, we enrolled 2,304 US military recruits from 4 basic training facilities to investigate AGE outbreaks among this population. Among enrollees, we detected norovirus in 433 (18.8%) AGE cases, and norovirus caused 49 AGE outbreaks during our longitudinal study. On average, each norovirus case-patient missed 1.2 training days due to illness, and 6.2% required infusion care. Whole-genome sequencing of selected samples from each outbreak produced full-length genomes (6,989–7,787 bp) for 39 samples. Norovirus GII.4 Sydney was the most (12/39, 30.8%) identified genotype over the study period. Phylogenetic and comparative genomic analyses revealed that several outbreak strains were responsible for causing >1 outbreak, even across different training sites. Our findings can inform infection control practices at military installations and overall norovirus vaccine development.
dc.format-
dc.language.isoEN
dc.publisherCenters for Disease Control and Prevention
dc.relation.uri['https://www.springernature.com/gp/open-research/policies/journal-policies/apc-waiver-countries', 'https://jhpn.biomedcentral.com/', 'https://jhpn.biomedcentral.com/submission-guidelines', 'https://jhpn.biomedcentral.com/about']
dc.rights['CC BY', 'CC BY-NC-ND']
dc.subject['global health', 'population health', 'health economics', 'nutrition', 'reproductive health', 'Nutritional diseases. Deficiency diseases', 'RC620-627', 'Public aspects of medicine', 'RA1-1270']
dc.subject.lccMedicine
dc.titleMolecular Characterization of Noroviruses Causing Acute Gastroenteritis Outbreaks among US Military Recruits, 2013–2023
dc.typeArticle
dc.description.keywordsNorovirus
dc.description.keywordsacute gastroenteritis
dc.description.keywordsAGE
dc.description.keywordsviruses
dc.description.keywordsenteric infections
dc.description.keywordsUS military
dc.description.pages71-79
dc.description.doi10.3201/eid3014.240307
dc.title.journalEmerging Infectious Diseases
dc.identifier.e-issn1080-6059
dc.identifier.oaioai:doaj.org/journal:33040794b3514c3c9eb74befe9f944ee
dc.journal.infoVolume 30, Issue 14


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