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De Novo Valve Tissue Morphology Following Bioscaffold Mitral Valve Replacement in a Juvenile Non-Human Primate Model

dc.contributor.authorBrittany A. Gonzalez
dc.contributor.authorMarcos Perez Gonzalez
dc.contributor.authorFrank Scholl
dc.contributor.authorSteven Bibevski
dc.contributor.authorElena Ladich
dc.contributor.authorJennifer Bibevski
dc.contributor.authorPablo Morales
dc.contributor.authorJesus Lopez
dc.contributor.authorMike Casares
dc.contributor.authorVincent Brehier
dc.contributor.authorLazaro Hernandez
dc.contributor.authorSharan Ramaswamy
dc.contributor.otherDepartment of Biomedical Engineering, Florida International University, Miami, FL 33174, USA
dc.contributor.otherDepartment of Biomedical Engineering, Florida International University, Miami, FL 33174, USA
dc.contributor.otherMemorial Healthcare System, Joe DiMaggio Children’s Hospital, Hollywood, FL 33021, USA
dc.contributor.otherDepartment of Biomedical Engineering, Florida International University, Miami, FL 33174, USA
dc.contributor.otherMemorial Healthcare System, Joe DiMaggio Children’s Hospital, Hollywood, FL 33021, USA
dc.contributor.otherCOR Veterinary Surgery Services, Hollywood, FL 33301, USA
dc.contributor.otherThe Mannheimer Foundation, Inc., Homestead, FL 33034, USA
dc.contributor.otherThe Mannheimer Foundation, Inc., Homestead, FL 33034, USA
dc.contributor.otherMemorial Healthcare System, Joe DiMaggio Children’s Hospital, Hollywood, FL 33021, USA
dc.contributor.otherMemorial Healthcare System, Joe DiMaggio Children’s Hospital, Hollywood, FL 33021, USA
dc.contributor.otherMemorial Healthcare System, Joe DiMaggio Children’s Hospital, Hollywood, FL 33021, USA
dc.contributor.otherDepartment of Biomedical Engineering, Florida International University, Miami, FL 33174, USA
dc.date.accessioned2021-07-23T14:30:58Z
dc.date.available2025-10-02T05:18:34Z
dc.date.issued01-07-2021
dc.identifier.issn-
dc.identifier.urihttps://www.mdpi.com/2306-5354/8/7/100
dc.description.abstractThe utility of implanting a bioscaffold mitral valve consisting of porcine small intestinal submucosa (PSIS) in a juvenile baboon model (12 to 14 months old at the time of implant; <i>n</i> = 3) to assess their in vivo tissue remodeling responses was investigated. Our findings demonstrated that the PSIS mitral valve exhibited the robust presence of de novo extracellular matrix (ECM) at all explantation time points (at 3-, 11-, and 20-months). Apart from a significantly lower level of proteoglycans in the implanted valve’s annulus region (<i>p</i> < 0.05) at 3 months compared to the 11- and 20-month explants, there were no other significant differences (<i>p</i> > 0.05) found between any of the other principal valve ECM components (collagen and elastin) at the leaflet, annulus, or chordae tendinea locations, across these time points. In particular, neochordae tissue had formed, which seamlessly integrated with the native papillary muscles. However, additional processing will be required to trigger accelerated, uniform and complete valve ECM formation in the recipient. Regardless of the specific processing done to the bioscaffold valve, in this proof-of-concept study, we estimate that a 3-month window following bioscaffold valve replacement is the timeline in which complete regeneration of the valve and integration with the host needs to occur.
dc.format-
dc.language.isoEN
dc.publisherMDPI AG
dc.relation.uri['https://www.springernature.com/gp/open-research/policies/journal-policies/apc-waiver-countries', 'https://www.nature.com/commseng/submit/submission-guidelines', 'https://www.nature.com/commseng/aims', 'https://www.nature.com/commseng/']
dc.rights['CC BY', 'CC BY-NC-ND']
dc.subject['engineering', 'Engineering (General). Civil engineering (General)', 'TA1-2040']
dc.subject.lccTechnology
dc.titleDe Novo Valve Tissue Morphology Following Bioscaffold Mitral Valve Replacement in a Juvenile Non-Human Primate Model
dc.typeArticle
dc.description.keywordsporcine small intestinal submucosa (PSIS)
dc.description.keywordsnon-human primate model
dc.description.keywordsmitral valve
dc.description.keywordsde novo valve tissues
dc.description.keywordsspatial intensity mapping
dc.description.keywordsextracellular matrix
dc.description.pages-
dc.description.doi10.3390/bioengineering8070100
dc.title.journalBioengineering
dc.identifier.e-issn2306-5354
dc.identifier.oaioai:doaj.org/journal:5b50a9bfdadf482791c9381c52cb05ef
dc.journal.infoVolume 8, Issue 7


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