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Biodistribution of Poly(alkyl cyanoacrylate) Nanoparticles in Mice and Effect on Tumor Infiltration of Macrophages into a Patient-Derived Breast Cancer Xenograft

dc.contributor.authorAbhilash D. Pandya
dc.contributor.authorTore-Geir Iversen
dc.contributor.authorSiver Moestue
dc.contributor.authorMaria T. Grinde
dc.contributor.authorÝrr Mørch
dc.contributor.authorSofie Snipstad
dc.contributor.authorAndreas K. O. Åslund
dc.contributor.authorGeir F. Øy
dc.contributor.authorWanja Kildal
dc.contributor.authorOlav Engebråten
dc.contributor.authorKirsten Sandvig
dc.contributor.authorTore Skotland
dc.contributor.authorGunhild M. Mælandsmo
dc.contributor.otherDepartment of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, 0379 Oslo, Norway
dc.contributor.otherDepartment of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, 0379 Oslo, Norway
dc.contributor.otherDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway
dc.contributor.otherDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, 7491 Trondheim, Norway
dc.contributor.otherSINTEF AS, Department of Biotechnology and Nanomedicine, 7034 Trondheim, Norway
dc.contributor.otherSINTEF AS, Department of Biotechnology and Nanomedicine, 7034 Trondheim, Norway
dc.contributor.otherSINTEF AS, Department of Biotechnology and Nanomedicine, 7034 Trondheim, Norway
dc.contributor.otherDepartment of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, 0379 Oslo, Norway
dc.contributor.otherInstitute for Cancer Genetics and Informatics, Oslo University Hospital, The Norwegian Radium Hospital, 0379 Oslo, Norway
dc.contributor.otherDepartment of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, 0379 Oslo, Norway
dc.contributor.otherDepartment of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, 0379 Oslo, Norway
dc.contributor.otherDepartment of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, 0379 Oslo, Norway
dc.contributor.otherDepartment of Tumor Biology, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, 0379 Oslo, Norway
dc.date.accessioned2021-04-29T00:02:03Z
dc.date.available2025-10-02T05:28:58Z
dc.date.issued01-04-2021
dc.identifier.issn-
dc.identifier.urihttps://www.mdpi.com/2079-4991/11/5/1140
dc.description.abstractWe have investigated the biodistribution and tumor macrophage infiltration after intravenous injection of the poly(alkyl cyanoacrylate) nanoparticles (NPs): PEBCA (poly(2-ethyl-butyl cyanoacrylate), PBCA (poly(n-butyl cyanoacrylate), and POCA (poly(octyl cyanoacrylate), in mice. These NPs are structurally similar, have similar PEGylation, and have previously been shown to give large variations in cellular responses in vitro. The PEBCA NPs had the highest uptake both in the patient-derived breast cancer xenograft MAS98.12 and in lymph nodes, and therefore, they are the most promising of these NPs for delivery of cancer drugs. High-resolution magic angle spinning magnetic resonance (HR MAS MR) spectroscopy did not reveal any differences in the metabolic profiles of tumors following injection of the NPs, but the PEBCA NPs resulted in higher tumor infiltration of the anti-tumorigenic M1 macrophages than obtained with the two other NPs. The PEBCA NPs also increased the ratio of M1/M2 (anti-tumorigenic/pro-tumorigenic) macrophages in the tumors, suggesting that these NPs might be used both as a vehicle for drug delivery and to modulate the immune response in favor of enhanced therapeutic effects.
dc.format-
dc.language.isoEN
dc.publisherMDPI AG
dc.relation.uri['https://www.springernature.com/gp/open-research/policies/journal-policies/apc-waiver-countries', 'https://www.nature.com/bdjopen/about/aims', 'https://www.nature.com/bdjopen/', 'https://www.nature.com/documents/BDJ_Open_Guide_for_Authors_16-07-18.pdf']
dc.rightsCC BY
dc.subject['dentistry', 'oral health', 'Dentistry', 'RK1-715']
dc.subject.lccChemistry
dc.titleBiodistribution of Poly(alkyl cyanoacrylate) Nanoparticles in Mice and Effect on Tumor Infiltration of Macrophages into a Patient-Derived Breast Cancer Xenograft
dc.typeArticle
dc.description.keywordspoly(alkyl cyanoacrylate) nanoparticles
dc.description.keywordsbreast cancer
dc.description.keywordsbiodistribution
dc.description.keywordsmacrophage infiltration
dc.description.keywordsmagnetic resonance spectroscopy
dc.description.pages-
dc.description.doi10.3390/nano11051140
dc.title.journalNanomaterials
dc.identifier.e-issn2079-4991
dc.identifier.oaioai:doaj.org/journal:8c550cf215934d1a9f834853b4184879
dc.journal.infoVolume 11, Issue 5


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