Show simple item record

Molecular and functional characterization of Schistosoma japonicum annexin A13

dc.contributor.authorHaoran Zhong
dc.contributor.authorLing Hou
dc.contributor.authorFanglin Qin
dc.contributor.authorYuqi Ren
dc.contributor.authorBowen Dong
dc.contributor.authorDanlin Zhu
dc.contributor.authorHao Li
dc.contributor.authorKe Lu
dc.contributor.authorZhiqiang Fu
dc.contributor.authorJinming Liu
dc.contributor.authorShaopeng Gu
dc.contributor.authorYamei Jin
dc.contributor.otherNational Reference Laboratory for Animal Schistosomiasis, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences
dc.contributor.otherCollege of Animal Science and Veterinary Medicine, Shanxi Agricultural University
dc.contributor.otherCollege of Life Sciences, Shanghai Normal University
dc.contributor.otherNational Reference Laboratory for Animal Schistosomiasis, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences
dc.contributor.otherNational Reference Laboratory for Animal Schistosomiasis, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences
dc.contributor.otherNational Reference Laboratory for Animal Schistosomiasis, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences
dc.contributor.otherNational Reference Laboratory for Animal Schistosomiasis, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences
dc.contributor.otherNational Reference Laboratory for Animal Schistosomiasis, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences
dc.contributor.otherNational Reference Laboratory for Animal Schistosomiasis, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences
dc.contributor.otherNational Reference Laboratory for Animal Schistosomiasis, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences
dc.contributor.otherCollege of Animal Science and Veterinary Medicine, Shanxi Agricultural University
dc.contributor.otherNational Reference Laboratory for Animal Schistosomiasis, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences
dc.date.accessioned2023-12-10T12:28:18Z
dc.date.accessioned2025-10-08T08:06:57Z
dc.date.available2025-10-08T08:06:57Z
dc.date.issued2023-12
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/35608
dc.description.abstractAbstract Schistosomiasis is a neglected tropical disease that affects humans and animals in tropical and subtropical regions worldwide. Schistosome eggs are responsible for the pathogenesis and transmission of schistosomiasis, thus reducing egg production is vital for prevention and control of schistosomiasis. However, the mechanisms underlying schistosome reproduction remain unclear. Annexin proteins (ANXs) are involved in the physiological and pathological functions of schistosomes, but the specific regulatory mechanisms and roles of ANX A13 in the development of Schistosoma japonicum and host–parasite interactions remain poorly understood. Therefore, in this study, the expression profiles of SjANX A13 at different life cycle stages of S. japonicum were assessed using quantitative PCR. In addition, the expression profiles of the homolog in S. mansoni were analyzed in reference to public datasets. The results of RNA interference showed that knockdown of SjANX A13 significantly affected the development and egg production of female worms in vivo. The results of an immune protection assay showed that recombinant SjANX A13 increased production of immunoglobulin G-specific antibodies. Finally, co-culture of S. japonicum exosomes with LX-2 cells using a transwell system demonstrated that SjANX A13 is involved in host–parasite interactions via exosomes. Collectively, these results will help to clarify the roles of SjANX A13 in the development of S. japonicum and host–parasite interactions as a potential vaccine candidate.
dc.language.isoEN
dc.publisherBMC
dc.subject.lccVeterinary medicine
dc.titleMolecular and functional characterization of Schistosoma japonicum annexin A13
dc.typeArticle
dc.description.keywordsSchistosoma japonicum
dc.description.keywordsannexin A13
dc.description.keywordsdevelopment
dc.description.keywordsimmune protection
dc.description.keywordshost–parasite interaction
dc.description.pages1-16
dc.description.doi10.1186/s13567-023-01244-z
dc.title.journalVeterinary Research
dc.identifier.e-issn1297-9716
dc.identifier.oai4ede3a611170464385f2bfead601d331
dc.journal.infoVolume 54, Issue 1


This item appears in the following Collection(s)

Show simple item record