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Senescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus

dc.contributor.authorShogo Ijima
dc.contributor.authorYuki Saito
dc.contributor.authorSena Yamamoto
dc.contributor.authorKentaro Nagaoka
dc.contributor.authorTaiki Iwamoto
dc.contributor.authorArisa Kita
dc.contributor.authorMaki Miyajima
dc.contributor.authorTsukasa Sato
dc.contributor.authorAkihiro Miyazaki
dc.contributor.authorTakako S. Chikenji
dc.contributor.otherDepartment of Oral Surgery, Sapporo Medical University School of Medicine
dc.contributor.otherDepartment of Anatomy, Sapporo Medical University School of Medicine
dc.contributor.otherGraduate School of Health Sciences, Hokkaido University
dc.contributor.otherDepartment of Anatomy, Sapporo Medical University School of Medicine
dc.contributor.otherDepartment of Anatomy, Sapporo Medical University School of Medicine
dc.contributor.otherDepartment of Anatomy, Sapporo Medical University School of Medicine
dc.contributor.otherGraduate School of Health Sciences, Hokkaido University
dc.contributor.otherGraduate School of Health Sciences, Hokkaido University
dc.contributor.otherDepartment of Oral Surgery, Sapporo Medical University School of Medicine
dc.contributor.otherGraduate School of Health Sciences, Hokkaido University
dc.date.accessioned2023-12-10T12:31:36Z
dc.date.accessioned2025-10-08T08:22:37Z
dc.date.available2025-10-08T08:22:37Z
dc.date.issued01-12-2023
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/35654
dc.description.abstractAbstract Oral lichen planus is a chronic inflammatory condition that adversely affects the oral mucosa; however, its etiology remains elusive. Consequently, therapeutic interventions for oral lichen planus are limited to symptomatic management. This study provides evidence of the accumulation of senescent mesenchymal cells, CD8 + T cells, and natural killer cells in patients with oral lichen planus. We profiled the patients’ tissues using the National Center for Biotechnology Information Gene Expression Omnibus database and found that senescence-related genes were upregulated in these tissues by gene set enrichment analysis. Immunohistochemical analysis showed increased senescent mesenchymal cells in the subepithelial layer of patients with oral lichen planus. Single-cell RNA-seq data retrieved from the Gene Expression Omnibus database of patients with oral lichen planus revealed that mesenchymal cells were marked by the upregulation of senescence-related genes. Cell-cell communication analysis using CellChat showed that senescent mesenchymal cells significantly influenced CD8 + T cells and natural killer cells via CXCL12-CXCR4 signaling, which is known to activate and recruit CD8 + T cells and NK cells. Finally, in vitro assays demonstrated that the secretion of senescence-associated factors from mesenchymal cells stimulated the activation of T cells and natural killer cells and promoted epithelial cell senescence and cytotoxicity. These findings suggest that the accumulation of mesenchymal cells with senescence-associated secretory phenotype may be a key driver of oral lichen planus pathogenesis.
dc.language.isoEN
dc.publisherBMC
dc.subject.lccImmunologic diseases. Allergy
dc.titleSenescence-associated secretory phenotypes in mesenchymal cells contribute to cytotoxic immune response in oral lichen planus
dc.typeArticle
dc.description.keywordsOral lichen planus
dc.description.keywordsSenescence
dc.description.keywordsSenescence-associated secretory phenotype
dc.description.keywordsMesenchymal cells
dc.description.keywordsGene set enrichment analysis
dc.description.keywordsSingle-cell RNA sequencing analysis
dc.description.pages1-15
dc.description.doi10.1186/s12979-023-00400-5
dc.title.journalImmunity & Ageing
dc.identifier.e-issn1742-4933
dc.identifier.oaibe1bd8eacb274330a5dcec62cca72835
dc.journal.infoVolume 20, Issue 1


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