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A systematic review with meta-analysis of the relation of aflatoxin B1 to growth impairment in infants/children

dc.contributor.authorBehnam Ghorbani Nejad
dc.contributor.authorZahra Mostafaei
dc.contributor.authorAli Balouchi Rezaabad
dc.contributor.authorFatemeh Mehravar
dc.contributor.authorMahtab Zarei
dc.contributor.authorAzadeh Dehghani
dc.contributor.authorMohammad Amin Raeisi Estabragh
dc.contributor.authorSomayyeh Karami-Mohajeri
dc.contributor.authorHamzeh Alizadeh
dc.contributor.otherDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Kerman University of Medical Sciences
dc.contributor.otherDepartment of Nutrition, Science and Research Branch, Islamic Azad University
dc.contributor.otherDepartment of Pharmacognosy, School of Pharmacy, Kerman University of Medical Sciences
dc.contributor.otherDepartment of Psychiatry and Community Health Nursing School of Nursing and Midwifery, Golestan University of Medical Sciences (GOUMS)
dc.contributor.otherDepartment of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences
dc.contributor.otherNutrition Research Center, Department of Community Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences
dc.contributor.otherPharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences
dc.contributor.otherPharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences
dc.contributor.otherGenetics Research Center, Department of Genetics and Breeding, The University of Guilan
dc.date.accessioned2023-12-10T12:31:56Z
dc.date.accessioned2025-10-08T08:22:44Z
dc.date.available2025-10-08T08:22:44Z
dc.date.issued01-12-2023
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/35662
dc.description.abstractAbstract Background Aflatoxins are regarded as the most potent genotoxic and carcinogenic type of mycotoxins. This meta-analysis was performed to investigate a the relation of aflatoxin B1 (AFB1) to growth measurements of infants/children, including wasting, underweight, stunting, as well as weight-for-age (WAZ), height-for-age (HAZ), and weight-for-height (WHZ) z-scores. Methods Electronic databases of PubMed, Web of Science, and Scopus were searched to identify related publications. Effect sizes for associations were pooled using the random effects analysis. Subgroup analysis by study design, method used to assess AFB1, and adjustment for covariateswas performed to detect possible sources of heterogeneity. Results Pooled analysis of available data showed that AFB1 exposure was negatively associated growth z-scores, including WHZ (β = -0.02, 95%CI = -0.07 to 0.03), with WAZ (β = -0.18, 95%CI = -0.33 to -0.02), and HAZ (β = -0.17, 95%CI = -0.30 to -0.03) in infants/children. There was a remarkable heterogeneity among studies on WAZ and HAZ (P ≤ 0.001). In prospective cohort studies, AFB1 exposure was found to be significantly associated with the elevated risk of underweight (OR = 1.20, 95%CI = 1.03 to 1.40) and stunting (OR = 1.21, 95%CI = 1.11 to 1.33). Conclusions This meta-analysis highlighted the importance of AFB1 exposure as a potential risk factor for growth impairment in infants/children.
dc.language.isoEN
dc.publisherBMC
dc.subject.lccPediatrics
dc.titleA systematic review with meta-analysis of the relation of aflatoxin B1 to growth impairment in infants/children
dc.typeArticle
dc.description.keywordsInfants
dc.description.keywordsChildren
dc.description.keywordsGrowth impairment
dc.description.keywordsAflatoxin
dc.description.pages1-15
dc.description.doi10.1186/s12887-023-04275-9
dc.title.journalBMC Pediatrics
dc.identifier.e-issn1471-2431
dc.identifier.oai1c250745b3a94212b3630a55c323d26a
dc.journal.infoVolume 23, Issue 1


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