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Antiviral Use in Mild-to-Moderate SARS-CoV-2 Infections during the Omicron Wave in Geriatric Patients

dc.contributor.authorNadia Exquis
dc.contributor.authorBenjamin Dionisi
dc.contributor.authorCaroline Flora Samer
dc.contributor.authorVictoria Rollason
dc.contributor.authorFrançois Curtin
dc.contributor.authorDina Zekry
dc.contributor.authorChristophe Graf
dc.contributor.authorVirgnie Prendki
dc.contributor.authorKuntheavy Ing Lorenzini
dc.contributor.otherDivision of Clinical Pharmacology and Toxicology, Department of Anesthesiology, Pharmacology, Intensive Care, and Emergency Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland
dc.contributor.otherDivision of Clinical Pharmacology and Toxicology, Department of Anesthesiology, Pharmacology, Intensive Care, and Emergency Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland
dc.contributor.otherDivision of Clinical Pharmacology and Toxicology, Department of Anesthesiology, Pharmacology, Intensive Care, and Emergency Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland
dc.contributor.otherDivision of Clinical Pharmacology and Toxicology, Department of Anesthesiology, Pharmacology, Intensive Care, and Emergency Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland
dc.contributor.otherDivision of Clinical Pharmacology and Toxicology, Department of Anesthesiology, Pharmacology, Intensive Care, and Emergency Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland
dc.contributor.otherFaculty of Medicine, University of Geneva, 1206 Geneva, Switzerland
dc.contributor.otherFaculty of Medicine, University of Geneva, 1206 Geneva, Switzerland
dc.contributor.otherFaculty of Medicine, University of Geneva, 1206 Geneva, Switzerland
dc.contributor.otherDivision of Clinical Pharmacology and Toxicology, Department of Anesthesiology, Pharmacology, Intensive Care, and Emergency Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland
dc.date.accessioned2024-06-26T15:35:57Z
dc.date.accessioned2025-10-08T08:24:08Z
dc.date.available2025-10-08T08:24:08Z
dc.date.issued01-05-2024
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/35759
dc.description.abstract(1) Background: Geriatric patients are at high risk of complications of Coronavirus disease-2019 (COVID-19) and are good candidates for antiviral drugs. (2) Methods: A retrospective study of electronic health records (EHRs) aiming to describe antiviral (nirmatrelvir and ritonavir (nirmatrelvir/r) or remdesivir) use, drug–drug interactions (DDIs) and adverse drug reactions (ADRs) in elderly patients (75 and over), hospitalized with mild-to-moderate COVID-19 between July 2022 and June 2023. (3) Results: Out of 491 patients (mean age: 86.9 years), 180 (36.7%) received nirmatrelvir/r, 78 (15.9%) received remdesivir, and 233 (47.4%) received no antiviral therapy. No association was found between the choice of antiviral and the demographic or medical data. No serious ADR was observed. Nirmatrelvir/r dosage adjustment was inadequate in 65% of patients with renal impairment. In total, 128 patients (71%) on nirmatrelvir/r had potential pharmacokinetic DDIs, with 43 resulting in a possibly related ADR. In the remdesivir group, pharmacodynamic DDIs were more frequent, with QTc prolongation risk in 56 patients (72%). Only 20 patients underwent follow-up ECG, revealing QTc prolongation in 4. (4) Conclusions: There is an underutilization of antivirals despite their justified indications. Nirmatrelvir/r dosage was rarely adjusted to renal function. Dose adjustments and closer monitoring are needed due to the high risk of drug interactions.
dc.language.isoEN
dc.publisherMDPI AG
dc.subject.lccMicrobiology
dc.titleAntiviral Use in Mild-to-Moderate SARS-CoV-2 Infections during the Omicron Wave in Geriatric Patients
dc.typeArticle
dc.description.keywordsCOVID-19
dc.description.keywordsremdesivir
dc.description.keywordsnirmatrelvir
dc.description.keywordsritonavir
dc.description.keywordsgeriatrics
dc.description.doi10.3390/v16060864
dc.title.journalViruses
dc.identifier.e-issn1999-4915
dc.identifier.oai8952adb20df54e65b09c4a1adce21aff
dc.journal.infoVolume 16, Issue 6


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