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Stimulator of Interferon Gene Agonists Induce an Innate Antiviral Response against Influenza Viruses

dc.contributor.authorHyun Jung Lee
dc.contributor.authorJoo-Hoo Park
dc.contributor.authorIl-Ho Park
dc.contributor.authorOk Sarah Shin
dc.contributor.otherBK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University Guro Hospital, Seoul 08308, Republic of Korea
dc.contributor.otherDepartment of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul 08308, Republic of Korea
dc.contributor.otherDepartment of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul 08308, Republic of Korea
dc.contributor.otherBK21 Graduate Program, Department of Biomedical Sciences, College of Medicine, Korea University Guro Hospital, Seoul 08308, Republic of Korea
dc.date.accessioned2024-06-26T15:35:33Z
dc.date.accessioned2025-10-08T08:24:09Z
dc.date.available2025-10-08T08:24:09Z
dc.date.issued01-05-2024
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/35763
dc.description.abstractThe devastating effects of COVID-19 have highlighted the importance of prophylactic and therapeutic strategies to combat respiratory diseases. Stimulator of interferon gene (STING) is an essential component of the host defense mechanisms against respiratory viral infections. Although the role of the cGAS/STING signaling axis in the innate immune response to DNA viruses has been thoroughly characterized, mounting evidence shows that it also plays a key role in the prevention of RNA virus infections. In this study, we investigated the role of STING activation during Influenza virus (IFV) infection. In both mouse bone marrow-derived macrophages and monocytic cell line THP-1 differentiated with PMA, we found that dimeric amidobenzimidazole (diABZI), a STING agonist, had substantial anti-IFV activity against multiple strains of IFV, including A/H1N1, A/H3N2, B/Yamagata, and B/Victoria. On the other hand, a pharmacological antagonist of STING (H-151) or the loss of STING in human macrophages leads to enhanced viral replication but suppressed IFN expression. Furthermore, diABZI was antiviral against IFV in primary air–liquid interface cultures of nasal epithelial cells. Our data suggest that STING agonists may serve as promising therapeutic antiviral agents to combat IFV.
dc.language.isoEN
dc.publisherMDPI AG
dc.subject.lccMicrobiology
dc.titleStimulator of Interferon Gene Agonists Induce an Innate Antiviral Response against Influenza Viruses
dc.typeArticle
dc.description.keywordsinfluenza virus
dc.description.keywordsSTING agonists
dc.description.keywordsdiABZI
dc.description.keywordsmacrophages
dc.description.keywordsair–liquid interface cultures
dc.description.doi10.3390/v16060855
dc.title.journalViruses
dc.identifier.e-issn1999-4915
dc.identifier.oaif699f94ab4304f91b9d482d62eedc1d3
dc.journal.infoVolume 16, Issue 6


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