| dc.contributor.author | Mehdi Bahmani | |
| dc.contributor.author | Hadi Esmaeili Gouvarchin Ghaleh | |
| dc.contributor.author | Javad Raouf Sarshoori | |
| dc.contributor.author | Seyed Mohammad Zarei | |
| dc.contributor.author | Ebrahim Salimi-Sabour | |
| dc.contributor.author | Masoomeh Shafaee | |
| dc.contributor.other | Pharmacy Student, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran | |
| dc.contributor.other | Assistant Professor, Department of Immunology, Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran | |
| dc.contributor.other | Assistant Professor, Department of Anatomical Sciences, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran | |
| dc.contributor.other | Assistant Professor, Department of Pharmacognosy and Traditional Pharmacy, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran | |
| dc.contributor.other | Assistant Professor, Department of Pharmacognosy and Traditional Pharmacy, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran | |
| dc.contributor.other | Ph.D Student in Chemistry, School of Chemistry, University College of Science, University of Tehran, Tehran, Iran | |
| dc.date.accessioned | 2023-12-11T09:06:01Z | |
| dc.date.accessioned | 2025-10-08T08:26:15Z | |
| dc.date.available | 2025-10-08T08:26:15Z | |
| dc.date.issued | 01-12-2023 | |
| dc.identifier.uri | http://digilib.fisipol.ugm.ac.id/repo/handle/15717717/35868 | |
| dc.description.abstract | Background and purpose: Healing burn wounds is considered to be a prominent medical issue, and the identification of a drug or substance that can effectively heal these wounds with minimal side effects is of great importance. The aim of the present study was to investigate the anti-inflammatory, antioxidant and restorative effects of the glandular sorrel plant on the experimental burn wound model in BALB/C mice.
Materials and methods: In this experimental-laboratory study, a total of 60 BALB/C mice were randomly assigned to 5 groups, each consisting of 12 mice. These groups included the control group, the cold cream sham group, the cream group containing the extract of the glandular sorrel plant, the Laagex cream group, and the group of the glandular sorrel leaf group. After second degree burns on days 3, 7, 14 and 21, wound healing variables include comparison of wound closure speed, inflammation, vascularization, epithelial regeneration, number of hair follicles, and number of strands. Collagen levels, inflammatory cytokines, antioxidant enzymes and liver enzymes were also examined.
Results: The results of the study indicated that the average inflammation, vascularization, epithelial regeneration, the number of hair follicles, the amount of collagen fibers and also the average of apparent wound closure in the groups treated with the cream containing the extract and leaves of the Rumex Tuberosus L. And Lajex cream has a significant difference (P<0.05) compared to the sham and control groups. In addition, the results showed a significant difference (P<0.05) in the serum level of inflammatory cytokines and antioxidant enzymes in the groups treated with the cream containing the extract and leaves of the Rumex Tuberosus L. and the Lajex cream compared to Sham and control groups. With regard to the liver enzymes, no significant changes were found between the studied groups (P<0.05).
Conclusion: Based on the findings of the study, it can be concluded that the tuberous sorrel plant is very efficient in the treatment of second degree burns and can be a good substitute for the currently available product. | |
| dc.language.iso | EN | |
| dc.publisher | Mazandaran University of Medical Sciences | |
| dc.subject.lcc | Medicine | |
| dc.title | Investigating the Anti-inflammatory, Antioxidant and Restorative Effects of Rumex tuberosus L. on the Experimental Burn Wound Model in BALB/c | |
| dc.type | Article | |
| dc.description.keywords | ethnobotany | |
| dc.description.keywords | inflammation scale | |
| dc.description.keywords | scale of angiogenesis | |
| dc.description.keywords | scale of re-epithelialization | |
| dc.description.keywords | scale of collagen fiber | |
| dc.description.keywords | measuring the number of hair follicles | |
| dc.description.keywords | inflammatory cytokines | |
| dc.description.keywords | antioxidant enzymes | |
| dc.description.pages | 13-26 | |
| dc.title.journal | Journal of Mazandaran University of Medical Sciences | |
| dc.identifier.e-issn | 1735-9279 | |
| dc.identifier.oai | ac03bad536394712b12b9bf867b2e0ca | |
| dc.journal.info | Volume 33, Issue 2 | |
