Show simple item record

Location‐specific pathology analysis of the monopodial pulmonary vasculature in a rabbit model of bronchopulmonary dysplasia—A pilot study

dc.contributor.authorJonas Labode
dc.contributor.authorDavid Haberthür
dc.contributor.authorRuslan Hlushchuk
dc.contributor.authorYannick Regin
dc.contributor.authorAndre George Gie
dc.contributor.authorThomas Salaets
dc.contributor.authorJaan Toelen
dc.contributor.authorChristian Mühlfeld
dc.contributor.otherHannover Medical School Institute of Functional and Applied Anatomy Hannover Germany
dc.contributor.otherInstitute of Anatomy University of Bern Bern Switzerland
dc.contributor.otherInstitute of Anatomy University of Bern Bern Switzerland
dc.contributor.otherDepartment of Development and Regeneration KU Leuven Leuven Belgium
dc.contributor.otherDepartment of Development and Regeneration KU Leuven Leuven Belgium
dc.contributor.otherDepartment of Development and Regeneration KU Leuven Leuven Belgium
dc.contributor.otherDepartment of Development and Regeneration KU Leuven Leuven Belgium
dc.contributor.otherHannover Medical School Institute of Functional and Applied Anatomy Hannover Germany
dc.date.accessioned2023-06-27T07:08:40Z
dc.date.accessioned2025-10-08T08:27:06Z
dc.date.available2025-10-08T08:27:06Z
dc.date.issued01-06-2023
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/35917
dc.description.abstractAbstract The mammalian pulmonary vasculature consists of functionally and morphologically heterogeneous compartments. When comparing sets of lungs, for example, in disease models or therapeutic interventions, local changes may be masked by the overall heterogeneity of the organ structure. Therefore, alterations taking place only in a sub‐compartment may not be detectable by global analysis. In the monopodial lung, the characterization of distinct vessel groups is difficult, due to the asymmetrical branching pattern. In this pilot study, a previously established method to classify segments of the monopodial pulmonary arterial tree into homogeneous groups was employed. To test its suitability for experimental settings, the method was applied to a hyperoxia (HYX, ≥95% oxygen) rabbit model of bronchopulmonary dysplasia and a normoxic control group (NOX, 21% oxygen). The method allowed the identification of morphological differences between the HYX and the NOX groups. Globally visible differences in lumen diameter were pinpointed to specific lung regions. Furthermore, local changes of wall dimension and cell layers in single compartments, that would not have been identifiable in an unfocused analysis of the whole dataset, were found. In conclusion, the described method achieves a higher precision in morphological studies of lung disease models, compared to a common, global analysis approach.
dc.language.isoEN
dc.publisherWiley
dc.subject.lccPhysiology
dc.titleLocation‐specific pathology analysis of the monopodial pulmonary vasculature in a rabbit model of bronchopulmonary dysplasia—A pilot study
dc.typeArticle
dc.description.keywordsbranching analysis
dc.description.keywordscluster analysis
dc.description.keywordslight microscopy
dc.description.keywordsmicrocomputed tomography
dc.description.keywordsmonopodial lung
dc.description.keywordspulmonary vasculature
dc.description.pagesn/a-n/a
dc.description.doi10.14814/phy2.15747
dc.title.journalPhysiological Reports
dc.identifier.e-issn2051-817X
dc.identifier.oai4b95f0b3784a4c15a162ac586e86b183
dc.journal.infoVolume 11, Issue 12


This item appears in the following Collection(s)

Show simple item record