| dc.contributor.author | Azizallah Dehghan | |
| dc.contributor.author | Leila Jahangiry | |
| dc.contributor.author | Rozhan Khezri | |
| dc.contributor.author | Alireza Jafari | |
| dc.contributor.author | Babak Pezeshki | |
| dc.contributor.author | Fatemeh Rezaei | |
| dc.contributor.author | Dagfinn Aune | |
| dc.contributor.other | Noncommunicable Diseases Research Center, Fasa University of Medical Sciences | |
| dc.contributor.other | Road Traffic Injury Research Center, Tabriz Health Services Management Research Center, Tabriz University of Medical Sciences | |
| dc.contributor.other | Student Research Committee, Iran University of Medical Sciences | |
| dc.contributor.other | Department of Health Education and Health Promotion, School of Health, Social Development and Health Promotion Research Center, Gonabad University of Medical Sciences | |
| dc.contributor.other | Noncommunicable Diseases Research Center, Fasa University of Medical Sciences | |
| dc.contributor.other | Research Center for Social Determinants of Health, Jahrom University of Medical Sciences | |
| dc.contributor.other | Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London | |
| dc.date.accessioned | 2024-06-30T11:24:12Z | |
| dc.date.accessioned | 2025-10-08T08:27:26Z | |
| dc.date.available | 2025-10-08T08:27:26Z | |
| dc.date.issued | 01-06-2024 | |
| dc.identifier.uri | http://digilib.fisipol.ugm.ac.id/repo/handle/15717717/35957 | |
| dc.description.abstract | Abstract Background Metabolic syndrome (MetS) is a cluster of risk factors and the Framingham risk score (FRS) is a useful metric for measuring the 10-year cardiovascular disease (CVD) risk of the population. The present study aimed to determine the 10-year risk of cardiovascular disease using the Framingham risk score in people with and without MetS in a large Iranian cohort study. Methods This cross-sectional study was done using the Fasa cohort. Participants aged ≥ 35 years old were recruited to the study from 2015 to 2016. The FRS was calculated using age, sex, current smoking, diabetes, systolic blood pressure (SBP), total cholesterol, and high-density lipoprotein (HDL) cholesterol. MetS was defined as the presence of three or more of the MetS risk factors including triglyceride (TG) level ≥ 150 mg dl− 1, HDL level < 40 mg dl− 1 in men and < 50 mg dl− 1 in women, systolic/diastolic blood pressure ≥ 130/≥85 mmHg or using medicine for hypertension, fasting blood sugar (FBS) level ≥ 100 mg dl− 1 or using diabetes medication and abdominal obesity considered as waist circumference (WC) ≥ 88 cm for women and ≥ 102 cm for men. Multiple logistic regressions were applied to estimate the 10- year CVD risk among people with and without MetS. Results Of 8949 participants, 1928 people (21.6%) had MetS. The mean age of the participants with and without Mets was 50.4 ± 9.2 years and 46.9 ± 9.1 years respectively. In total 15.3% of participants with MetS and 8.0% of participants without MetS were in the high-risk category of 10-year CVD risk. Among participants with MetS gender, TG, SBP, FBS and in people without MetS gender, TG, SBP, FBS, and HDL showed strong associations with the predicted 10-year CVD risk. Conclusion Male sex and increased SBP, TG, and FBS parameters were strongly associated with increased 10-year risk of CVD in people with and without MetS. In people without MetS, reduced HDL-cholestrol was strongly associated with increased 10-year risk of CVD. The recognition of participant’s TG, blood pressure (BP), FBS and planning appropriate lifestyle interventions related to these characteristics is an important step towards prevention of CVD. | |
| dc.language.iso | EN | |
| dc.publisher | BMC | |
| dc.subject.lcc | Diseases of the endocrine glands. Clinical endocrinology | |
| dc.title | Framingham risk scores for determination the 10-year risk of cardiovascular disease in participants with and without the metabolic syndrome: results of the Fasa Persian cohort study | |
| dc.type | Article | |
| dc.description.keywords | Cardiovascular disease | |
| dc.description.keywords | 10-year risk | |
| dc.description.keywords | Framingham risk score | |
| dc.description.keywords | Metabolic syndrome | |
| dc.description.pages | 1-9 | |
| dc.description.doi | 10.1186/s12902-024-01621-5 | |
| dc.title.journal | BMC Endocrine Disorders | |
| dc.identifier.e-issn | 1472-6823 | |
| dc.identifier.oai | 44376947e0224f44ad9030a75d2a6cf6 | |
| dc.journal.info | Volume 24, Issue 1 | |
