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Analysis of immunophenotypic features in hyaline vascular type Castleman disease

dc.contributor.authorYu Chang
dc.contributor.authorYu Ma
dc.contributor.authorChen Chang
dc.contributor.authorWensheng Li
dc.contributor.otherDepartment of Pathology, Shaanxi Provincial People’s Hospital, The Third Affiliated Hospital of Xi’an Jiaotong University Health Science Center
dc.contributor.otherDepartment of Pathology, Shaanxi Provincial People’s Hospital, The Third Affiliated Hospital of Xi’an Jiaotong University Health Science Center
dc.contributor.otherDepartment of Pathology, Shaanxi Provincial People’s Hospital, The Third Affiliated Hospital of Xi’an Jiaotong University Health Science Center
dc.contributor.otherDepartment of Pathology, Shaanxi Provincial People’s Hospital, The Third Affiliated Hospital of Xi’an Jiaotong University Health Science Center
dc.date.accessioned2023-12-10T12:05:32Z
dc.date.accessioned2025-10-08T08:27:27Z
dc.date.available2025-10-08T08:27:27Z
dc.date.issued01-12-2023
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/35959
dc.description.abstractAbstract Background Studies suggested that the immunophenotype of hyaline vascular type Castleman disease (HVCD) lacked characteristics, which was easy to be confused with other diseases. Methods From January 2010 to June 2022, 17 cases of HVCD were selected from the Department of Pathology of Shaanxi Provincial People’s Hospital and the Department of Pathology of Shaanxi Provincial Cancer Hospital. 13 cases of reactive hyperplastic lymph nodes (RHL) and 11 cases of follicular lymphoma (FL) were selected as the control group. All cases were performed CD3, CD20, CD21 and BCL2 immunohistochemical staining. Results (i) In 17 cases of HVCD, the negative area of BCL2 of germinal center was significantly smaller than the negative area of CD3 of germinal center. However, in 13 cases of RHL, the negative area of CD3 of germinal center was basically consistent with the negative area of germinal center of BCL2 of germinal center. In 11 cases of FL, in neoplastic follicles, the negative area of CD3 was basically consistent with the positive area of BCL2. The difference between HVCD group and other two groups of diseases was statistically significant (P < 0.05). (ii) In 17 cases of HVCD, the negative area of BCL2 of germinal center was significantly smaller than the follicular dendritic cell (FDC) meshworks expressed by CD21. However, in 13 cases of RHL, the FDC meshworks expressed by CD21 were basically consistent with the negative area of BCL2 of germinal center. In 11 cases of FL, in neoplastic follicles, the FDC meshworks expressed by CD21 was basically consistent with the positive area of BCL2. The difference between HVCD group and other two groups of disease was statistically significant (P < 0.05). Conclusions HVCD has unique immunophenotypic characteristics. The negative area of BCL2 of germinal center is significantly smaller than the negative area of CD3. The negative area of the BCL2 of germinal center is significantly smaller than the FDC meshworks expressed by CD21. These two immunophenotypic features in HVCD are very important in diagnosis and differential diagnosis.
dc.language.isoEN
dc.publisherBMC
dc.subject.lccPathology
dc.titleAnalysis of immunophenotypic features in hyaline vascular type Castleman disease
dc.typeArticle
dc.description.keywordsHyaline vascular type Castleman Disease
dc.description.keywordsImmunophenotypic features
dc.description.keywordsCD3
dc.description.keywordsCD21
dc.description.keywordsBCL2
dc.description.pages1-7
dc.description.doi10.1186/s13000-023-01421-w
dc.title.journalDiagnostic Pathology
dc.identifier.e-issn1746-1596
dc.identifier.oaif39b8236f8634536950961371d50e3bf
dc.journal.infoVolume 18, Issue 1


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