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Estimation of Genetic Parameters and Weighted Single-Step Genome-Wide Association Study for Indicators of Colostrum Quality in Chinese Holstein Cattle

dc.contributor.authorYehua Ma
dc.contributor.authorLuiz F. Brito
dc.contributor.authorTao An
dc.contributor.authorHailiang Zhang
dc.contributor.authorYao Chang
dc.contributor.authorShaohu Chen
dc.contributor.authorXin Wang
dc.contributor.authorLibing Bai
dc.contributor.authorGang Guo
dc.contributor.authorYachun Wang
dc.contributor.otherState Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, Laboratory of Animal Genetics, Breeding, and Reproduction, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
dc.contributor.otherDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA
dc.contributor.otherCollege of Animal Science, Xinjiang Agricultural University, Urumqi 830052, China
dc.contributor.otherState Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, Laboratory of Animal Genetics, Breeding, and Reproduction, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
dc.contributor.otherState Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, Laboratory of Animal Genetics, Breeding, and Reproduction, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
dc.contributor.otherDairy Association of China, Beijing 100193, China
dc.contributor.otherBeijing Sunlon Livestock Development Company Limited, Beijing 100029, China
dc.contributor.otherBeijing Sunlon Livestock Development Company Limited, Beijing 100029, China
dc.contributor.otherBeijing Sunlon Livestock Development Company Limited, Beijing 100029, China
dc.contributor.otherState Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, Laboratory of Animal Genetics, Breeding, and Reproduction, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
dc.date.accessioned2025-08-27T14:00:20Z
dc.date.accessioned2025-10-08T08:35:59Z
dc.date.available2025-10-08T08:35:59Z
dc.date.issued01-08-2025
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/36199
dc.description.abstractColostrum is the milk harvested during the first few hours after calving, which contains high levels of immunoglobulins, antimicrobial peptides, and growth factors essential for the health of neonates. The primary objective of this study was to investigate the genetic background of colostrum quality traits (based on Brix percentage) in Holstein cows. Using phenotypic records of 58,338 Holstein cows from 37 dairy farms, we identified significant systematic effects influencing colostrum quality measured by digital Brix refractometer, estimated genetic parameters, and performed weighted single-step genome-wide association studies (WssGWAS) to identify genomic regions and candidate genes associated with these traits. The average (±SD) Brix percentage was 23.76 ± 3.25%. With heritability values ranging from 0.21 ± 0.03 (Brix in third parity) to 0.30 ± 0.02 (Brix in second parity), colostrum quality was determined to be moderately heritable. Genetic correlations between colostrum quality across parities ranged from 0.37 ± 0.14 to 0.81 ± 0.13. For colostrum quality from cows in the first, second, and third parities, WssGWAS enabled the identification of 30, 32, and 38 genomic regions explaining 4.18%, 4.42%, and 5.58% of the total additive genetic variance, respectively. Two immune-related genes (<i>CNR1</i> and <i>ZXDC</i>) were identified as promising candidate genes for colostrum quality traits. In summary, colostrum quality measured in first parity cows should be evaluated as a different trait from measurements in later parities in breeding programs. These findings provide useful information for dairy breeders to genetically improve colostrum quality in dairy cattle populations.
dc.language.isoEN
dc.publisherMDPI AG
dc.subject.lccAgriculture (General)
dc.titleEstimation of Genetic Parameters and Weighted Single-Step Genome-Wide Association Study for Indicators of Colostrum Quality in Chinese Holstein Cattle
dc.typeArticle
dc.description.keywordscolostrum quality
dc.description.keywordsgenetic analysis
dc.description.keywordscandidate gene
dc.description.keywordsdairy cow
dc.description.doi10.3390/agriculture15161763
dc.title.journalAgriculture
dc.identifier.e-issn2077-0472
dc.identifier.oaioai:doaj.org/journal:a55ac769f6c94134b98f662190142bc3
dc.journal.infoVolume 15, Issue 16


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