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Pharmacokinetics and antibacterial activity of tiamulin after single and multiple oral administrations in geese

dc.contributor.authorIrene Sartini
dc.contributor.authorCristina Vercelli
dc.contributor.authorBeata Lebkowska-Wieruszewska
dc.contributor.authorAndrzej Lisowski
dc.contributor.authorCharbel Fadel
dc.contributor.authorAmnart Poapolathep
dc.contributor.authorFilomena Dessì
dc.contributor.authorMario Giorgi
dc.contributor.otherDepartment of Veterinary Medicine, University of Sassari, Sassari, Italy
dc.contributor.otherDepartment of Veterinary Sciences, University of Turin, Torino, Italy
dc.contributor.otherDepartment of Pharmacology, University of Life Sciences, Lublin, Poland
dc.contributor.otherDepartment of Biology and Animal Breeding, University of Life Sciences, Lublin, Poland
dc.contributor.otherDepartment of Veterinary Medicine, University of Sassari, Sassari, Italy
dc.contributor.otherDepartment of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand
dc.contributor.otherDepartment of Veterinary Medicine, University of Sassari, Sassari, Italy
dc.contributor.otherDepartment of Veterinary Medicine, University of Sassari, Sassari, Italy; Department of Veterinary Sciences, University of Pisa, Via Livornese (lato monte), 56122, San Piero a Grado, Pisa, Italy; Corresponding author.
dc.date.accessioned2023-10-25T04:16:35Z
dc.date.accessioned2025-10-08T08:46:10Z
dc.date.available2025-10-08T08:46:10Z
dc.date.issued01-12-2023
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/37074
dc.description.abstractTiamulin is an antibiotic approved exclusively in veterinary medicine, active against G-positive bacteria as well as Mycoplasma spp. and Leptospirae spp. The study was aimed to establish its pharmacokinetics and to evaluate drug effects on resistance in cloacal flora in vivo in geese. Eight healthy geese underwent to a two-phase longitudinal study (60 mg/kg single oral administration vs 60 mg/kg/day for 4 days) with a two-week wash-out period. Blood samples and cloacal swabs were collected at pre-assigned times. Minimal inhibitory concentration (MIC) has been evaluated for each isolated bacterial species. The pharmacokinetic parameters that significantly differed between the groups were Cmax (p = 0.024), AUC0-t (p = 0.031), AUC0-inf (p = 0.038), t1/2kel (p = 0.021), Cl/F (p = 0.036), and Vd/F (p = 0.012). Tiamulin exhibited a slow to moderate terminal half-life (3.13 h single; 2.62 h multiple) and a rapid absorption (1 h single; 0.5 h multiple) in geese, with an accumulation ratio of 1.8 after multiple doses. An in-silico simulation of multiple dosing did not reflect the results of the in vivo multiple dosage study. In both treatments, the MIC values were very high demonstrating a resistance (> 64 μg/ml) against tiamulin that can be present prior the drug administration for some strains, or emerge shortly after the commencing of treatment for some others.
dc.language.isoEN
dc.publisherElsevier
dc.subject.lccVeterinary medicine
dc.titlePharmacokinetics and antibacterial activity of tiamulin after single and multiple oral administrations in geese
dc.typeArticle
dc.description.keywordsGoose
dc.description.keywordsOral
dc.description.keywordsPharmacodynamics
dc.description.keywordsPharmacokinetics
dc.description.keywordsTiamulin
dc.description.doi10.1016/j.vas.2023.100317
dc.title.journalVeterinary and Animal Science
dc.identifier.e-issn2451-943X
dc.identifier.oaioai:doaj.org/journal:1d501a02b3d14996a92f8010f7b620dc


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