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A Simple and Fast Battery Test for Phenotypic Characterization of Mice

dc.contributor.authorMariana Garcia-Gomes
dc.contributor.authorDennis Zanatto
dc.contributor.authorPedro Yamamoto
dc.contributor.authorDanilo Wadt
dc.contributor.authorAna Antiorio
dc.contributor.authorJilma Aleman-Laporte
dc.contributor.authorSandra Alexandre-Ribeiro
dc.contributor.authorGuilherme Marson
dc.contributor.authorCezar Guizzo
dc.contributor.authorSilvia Massironi
dc.contributor.authorMaria Bernardi
dc.contributor.authorClaudia Mori
dc.contributor.otherDepartment of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo (USP), São Paulo, Brazil
dc.contributor.otherDepartment of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo (USP), São Paulo, Brazil
dc.contributor.otherDepartment of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo (USP), São Paulo, Brazil
dc.contributor.otherDepartment of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo (USP), São Paulo, Brazil
dc.contributor.otherDepartment of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo (USP), São Paulo, Brazil
dc.contributor.otherDepartment of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo (USP), São Paulo, Brazil
dc.contributor.otherDepartment of Immunology, Institute of Biomedical Science, University of São Paulo (USP), São Paulo, Brazil
dc.contributor.otherChemistry Department, Institute of Chemistry, University of São Paulo (USP), São Paulo, Brazil
dc.contributor.otherChemistry Department, Institute of Chemistry, University of São Paulo (USP), São Paulo, Brazil
dc.contributor.otherDepartment of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo (USP), São Paulo, Brazil
dc.contributor.otherGraduate Program in Environmental and Experimental Pathology, Paulista University, São Paulo, Brazil
dc.contributor.otherDepartment of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo (USP), São Paulo, Brazil
dc.date.accessioned2024-06-05T02:09:40Z
dc.date.accessioned2025-10-08T08:56:58Z
dc.date.available2025-10-08T08:56:58Z
dc.date.issued01-04-2020
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/38314
dc.description.abstractDespite the great number of test batteries already known to assess the behavior of genetically modified and inbred strains of mice, only a few of them focus on basic neurological parameters. The purpose of the battery test proposed is to settle a specific methodology to characterize the phenotype of neurological disease models in mutant or genetically modified mice. This methodology is simple and efficient in order to analyze several parameters, including general activity, sensory nervous system, sensorimotor system, central nervous system and autonomous nervous system. This can aid the choice of specific additional tests as well as the determination of an interrelationship among phenotypic alterations observed. Although being efficient for a first analysis of a mouse model, interpretation of the results must be carefully made because phenotype manifestation may vary due to many parameters, including mouse strain, environmental and housing condition, animal-experimenter interaction, sample size and tests order. It is important to consider as a critical point if handling procedures are aversive. The results acquired with the analysis of 18 parameters together provide preliminary data to characterize mouse phenotype and helps selecting more specific tests.
dc.language.isoEN
dc.publisherBio-protocol LLC
dc.subject.lccBiology (General)
dc.titleA Simple and Fast Battery Test for Phenotypic Characterization of Mice
dc.typeArticle
dc.description.doi10.21769/BioProtoc.3568
dc.title.journalBio-Protocol
dc.identifier.e-issn2331-8325
dc.identifier.oaioai:doaj.org/journal:f23ab6b01e8f46b2819e42c686bdd615
dc.journal.infoVolume 10, Issue 7


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