| dc.contributor.author | Rui Liu | |
| dc.contributor.author | Rui Liu | |
| dc.contributor.author | GuanZhong Gong | |
| dc.contributor.author | KangNing Meng | |
| dc.contributor.author | KangNing Meng | |
| dc.contributor.author | ShanShan Du | |
| dc.contributor.author | Yong Yin | |
| dc.contributor.other | Department of Graduate, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China | |
| dc.contributor.other | Department of Radiation Oncology Physics and Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China | |
| dc.contributor.other | Department of Radiation Oncology Physics and Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China | |
| dc.contributor.other | Department of Graduate, Shandong First Medical University, Shandong Academy of Medical Sciences, Jinan, China | |
| dc.contributor.other | Department of Radiation Oncology Physics and Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China | |
| dc.contributor.other | Department of Radiation Oncology Physics and Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China | |
| dc.contributor.other | Department of Radiation Oncology Physics and Technology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China | |
| dc.date.accessioned | 2024-01-24T04:44:58Z | |
| dc.date.accessioned | 2025-10-08T08:59:16Z | |
| dc.date.available | 2025-10-08T08:59:16Z | |
| dc.date.issued | 01-01-2024 | |
| dc.identifier.uri | http://digilib.fisipol.ugm.ac.id/repo/handle/15717717/38455 | |
| dc.description.abstract | Whole-brain radiotherapy (WBRT) plays an irreplaceable role in the treatment of brain metastases (BMs), but cognitive decline after WBRT seriously affects patients’ quality of life. The development of cognitive dysfunction is closely related to hippocampal injury, but standardized criteria for predicting hippocampal injury and dose limits for hippocampal protection have not yet been developed. This review systematically reviews the clinical efficacy of hippocampal avoidance - WBRT (HA-WBRT), the controversy over dose limits, common methods and characteristics of hippocampal imaging and segmentation, differences in hippocampal protection by common radiotherapy (RT) techniques, and the application of artificial intelligence (AI) and radiomic techniques for hippocampal protection. In the future, the application of new techniques and methods can improve the consistency of hippocampal dose limit determination and the prediction of the occurrence of cognitive dysfunction in WBRT patients, avoiding the occurrence of cognitive dysfunction in patients and thus benefiting more patients with BMs. | |
| dc.language.iso | EN | |
| dc.publisher | Frontiers Media S.A. | |
| dc.subject.lcc | Neoplasms. Tumors. Oncology. Including cancer and carcinogens | |
| dc.title | Hippocampal sparing in whole-brain radiotherapy for brain metastases: controversy, technology and the future | |
| dc.type | Article | |
| dc.description.keywords | hippocampus avoidance | |
| dc.description.keywords | brain metastases | |
| dc.description.keywords | whole brain radiotherapy | |
| dc.description.keywords | new radiotherapy techniques | |
| dc.description.keywords | contour | |
| dc.description.keywords | dose limits | |
| dc.description.doi | 10.3389/fonc.2024.1342669 | |
| dc.title.journal | Frontiers in Oncology | |
| dc.identifier.e-issn | 2234-943X | |
| dc.identifier.oai | oai:doaj.org/journal:bce1784a0f2444d182418bbb62d9961d | |
