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Remdesivir Derivative VV116 Is a Potential Broad-Spectrum Inhibitor of Both Human and Animal Coronaviruses

dc.contributor.authorWeiyong Liu
dc.contributor.authorMin Zhang
dc.contributor.authorChengxiu Hu
dc.contributor.authorHuijuan Song
dc.contributor.authorYi Mei
dc.contributor.authorYingle Liu
dc.contributor.authorQi Zhang
dc.contributor.otherDepartment of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
dc.contributor.otherDepartment of Emergency Medicine, The Third People’s Hospital of Hubei Province, Wuhan 430033, China
dc.contributor.otherDepartment of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
dc.contributor.otherDepartment of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
dc.contributor.otherState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
dc.contributor.otherState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
dc.contributor.otherState Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
dc.date.accessioned2023-12-22T14:48:59Z
dc.date.accessioned2025-10-08T09:03:38Z
dc.date.available2025-10-08T09:03:38Z
dc.date.issued01-11-2023
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/38733
dc.description.abstractCoronaviruses represent a significant threat to both human and animal health, encompassing a range of pathogenic strains responsible for illnesses, from the common cold to more severe diseases. VV116 is a deuterated derivative of Remdesivir with oral bioavailability that was found to potently inhibit SARS-CoV-2. In this work, we investigated the broad-spectrum antiviral activity of VV116 against a variety of human and animal coronaviruses. We examined the inhibitory effects of VV116 on the replication of the human coronaviruses HCoV-NL63, HCoV-229E, and HCoV-OC43, as well as the animal coronaviruses MHV, FIPV, FECV, and CCoV. The findings reveal that VV116 effectively inhibits viral replication across these strains without exhibiting cytotoxicity, indicating its potential for safe therapeutic use. Based on the results of a time-of-addition assay and an rNTP competitive inhibition assay, it is speculated that the inhibitory mechanism of VV116 against HCoV-NL63 is consistent with its inhibition of SARS-CoV-2. Our work presents VV116 as a promising candidate for broad-spectrum anti-coronavirus therapy, with implications for both human and animal health, and supports the expansion of its therapeutic applications as backed by detailed experimental data.
dc.language.isoEN
dc.publisherMDPI AG
dc.subject.lccMicrobiology
dc.titleRemdesivir Derivative VV116 Is a Potential Broad-Spectrum Inhibitor of Both Human and Animal Coronaviruses
dc.typeArticle
dc.description.keywordsremdesivir
dc.description.keywordsVV116
dc.description.keywordscoronavirus
dc.description.keywordsbroad-spectrum anti-coronavirus activity
dc.description.doi10.3390/v15122295
dc.title.journalViruses
dc.identifier.e-issn1999-4915
dc.identifier.oaioai:doaj.org/journal:b7838cabeb8449629907ef09a0c889f8
dc.journal.infoVolume 15, Issue 12


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