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Cardiomyopathy Does Not Exacerbate the Severity of Pneumonia Caused by a SARS-CoV-2 Delta Variant in the J2N-k Hamster Model

dc.contributor.authorKiyoko Iwatsuki-Horimoto
dc.contributor.authorMutsumi Ito
dc.contributor.authorMoe Okuda-Hamabata
dc.contributor.authorHisayoshi Takagi
dc.contributor.authorMasaki Imai
dc.contributor.authorYoshihiro Kawaoka
dc.contributor.otherDivision of Virology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
dc.contributor.otherDivision of Virology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
dc.contributor.otherDivision of Virology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
dc.contributor.otherJapan SLC, Inc., Hamamatsu, Shizuoka 433-8114, Japan
dc.contributor.otherDivision of Virology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
dc.contributor.otherDivision of Virology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan
dc.date.accessioned2023-12-22T14:48:55Z
dc.date.accessioned2025-10-08T09:04:09Z
dc.date.available2025-10-08T09:04:09Z
dc.date.issued01-11-2023
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/38761
dc.description.abstractCardiovascular disease is one of many risk factors that have been linked to increased severity or mortality in coronavirus disease 2019 (COVID-19) patients; however, the exact role of SARS-CoV-2 in the pathogenesis of cardiac inflammatory injury has not been established. A previous study reported that SARS-CoV-2 causes more severe disease with cardiomyopathy in a J2N-k animal model. Here, we investigated the sensitivity of J2N-k hamsters, as a cardiomyopathy animal model, to a delta strain of SARS-CoV-2 compared to J2N-n control animals. We found that J2N-k hamsters were less susceptible to this delta strain than J2N-n animals, and we found no evidence that cardiomyopathy is a risk factor in this animal model. Since the previous study reported that SARS-CoV-2 causes more severe disease with cardiomyopathy in the same animal model, further analysis of the relationship between cardiomyopathy and SARS-CoV-2 infection is needed.
dc.language.isoEN
dc.publisherMDPI AG
dc.subject.lccMicrobiology
dc.titleCardiomyopathy Does Not Exacerbate the Severity of Pneumonia Caused by a SARS-CoV-2 Delta Variant in the J2N-k Hamster Model
dc.typeArticle
dc.description.keywordsSARS-CoV-2
dc.description.keywordsCOVID-19
dc.description.keywordscardiomyopathy
dc.description.keywordsrisk factor
dc.description.keywordsanimal model
dc.description.keywordsSyrian hamster
dc.description.doi10.3390/v15122280
dc.title.journalViruses
dc.identifier.e-issn1999-4915
dc.identifier.oaioai:doaj.org/journal:35bedbc2a93442418fdee8199a400423
dc.journal.infoVolume 15, Issue 12


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