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Role of High-Fat Diet Alone on Lipids, Arterial Wall and Hippocampal Neural Cell Alterations in Animal Models and Their Implications for Humans

dc.contributor.authorGayathri S. Prabhu
dc.contributor.authorMohandas Rao KG
dc.contributor.authorPreethi Lavina Concessao
dc.contributor.authorKiranmai S. Rai
dc.contributor.otherDivision of Anatomy, Department of Basic Medical Sciences, Manipal Academy of Higher Education, Manipal 576104, India
dc.contributor.otherDivision of Anatomy, Department of Basic Medical Sciences, Manipal Academy of Higher Education, Manipal 576104, India
dc.contributor.otherDivision of Physiology, Department of Basic Medical Sciences, Manipal Academy of Higher Education, Manipal 576104, India
dc.contributor.otherDivision of Physiology, Department of Basic Medical Sciences, Manipal Academy of Higher Education, Manipal 576104, India
dc.date.accessioned2025-08-27T14:12:23Z
dc.date.accessioned2025-10-08T09:11:31Z
dc.date.available2025-10-08T09:11:31Z
dc.date.issued01-08-2025
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/39291
dc.description.abstractBackground: A high-fat diet has been shown to have an impact on metabolism resulting in changes in arterial wall thickness and degeneration of surviving neural cells of the hippocampus. The present review focuses on the various animal models used to induce high-fat diet conditions for studying obesity-induced atherosclerosis, along with the associated changes observed in surviving neural cells of the hippocampus. It also highlights the limitations of rodent models and discusses their implications for human research. Methods: The sources for the literature search were Scopus, PubMed, Medline and Google Scholar. Both animal and human studies published were considered and are cited. Results: High-fat-diet-induced vascular changes, mainly in the tunica media, has been shown to have more impact on medium-sized arteries and on the Cornu Ammonis three subregions and outer dentatae gyrus of the hippocampus. Conclusions: High-fat-diet-induced neurovascular changes have been studied radically in animal models, and more supporting studies representing preclinical research should be advanced to humans.
dc.language.isoEN
dc.publisherMDPI AG
dc.subject.lccBiology (General)
dc.titleRole of High-Fat Diet Alone on Lipids, Arterial Wall and Hippocampal Neural Cell Alterations in Animal Models and Their Implications for Humans
dc.typeArticle
dc.description.keywordshigh-fat diet
dc.description.keywordsobesity
dc.description.keywordsanimal models
dc.description.keywordslipids
dc.description.keywordsatherosclerosis
dc.description.keywordshippocampus
dc.description.doi10.3390/biology14080971
dc.title.journalBiology
dc.identifier.e-issn2079-7737
dc.identifier.oaioai:doaj.org/journal:777ae92391e443eabd2c775326f29448
dc.journal.infoVolume 14, Issue 8


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