| dc.contributor.author | Chong Zheng | |
| dc.contributor.author | Rongtong Li | |
| dc.contributor.author | Chaoxiong Shen | |
| dc.contributor.author | Zhizhou Hu | |
| dc.contributor.author | Zhongming Qiu | |
| dc.contributor.author | Qingwu Yang | |
| dc.contributor.author | Fang Guo | |
| dc.contributor.other | Neurology Department, Longyan First Affiliated Hospital of Fujian Medical University, No. 105, Jiuyi North Road, Longyan 364000, China; Corresponding author. Neurology Department, Longyan First Affiliated Hospital of Fujian Medical University, No. 105, Jiuyi North Road, Longyan 364000, Fujian, China. | |
| dc.contributor.other | Neurology Department, Longyan First Affiliated Hospital of Fujian Medical University, No. 105, Jiuyi North Road, Longyan 364000, China | |
| dc.contributor.other | Neurology Department, Longyan First Affiliated Hospital of Fujian Medical University, No. 105, Jiuyi North Road, Longyan 364000, China | |
| dc.contributor.other | Neurology Department, Longyan First Affiliated Hospital of Fujian Medical University, No. 105, Jiuyi North Road, Longyan 364000, China | |
| dc.contributor.other | Neurology Department, Xinqiao Hospital and the Second Affiliated Hospital, Army Medical University (Third Military Medical University) 183 Xinqiao Main Street, Shapingba District, Chongqing 400037, China | |
| dc.contributor.other | Neurology Department, Xinqiao Hospital and the Second Affiliated Hospital, Army Medical University (Third Military Medical University) 183 Xinqiao Main Street, Shapingba District, Chongqing 400037, China | |
| dc.contributor.other | Neurology Department, Longyan First Affiliated Hospital of Fujian Medical University, No. 105, Jiuyi North Road, Longyan 364000, China | |
| dc.date.accessioned | 2025-08-27T04:48:53Z | |
| dc.date.accessioned | 2025-10-08T09:12:10Z | |
| dc.date.available | 2025-10-08T09:12:10Z | |
| dc.date.issued | 01-09-2025 | |
| dc.identifier.uri | http://digilib.fisipol.ugm.ac.id/repo/handle/15717717/39357 | |
| dc.description.abstract | Background and purpose: To evaluate the effectiveness and safety of intravenous tirofiban before endovascular thrombectomy in subgroups of acute ischemic stroke patients with different degrees of leukoaraiosis (LA). Methods: Patients of the RESCUE BT trial whose LA grade could be assessed were included. Eligible patients were dichotomized into two strata according to the van Swieten scale (VSS) score, absent-to-moderate LA (VSS score <3) and severe LA (VSS score ≥3). Furthermore, patients were divided into tirofiban and placebo groups in each stratum. The primary outcome was the 90-day modified Rankin Scale (mRS) score. Safety outcome was radiological intracranial hemorrhage within 48 h. Results: 861 patients were included, 439 patients with absent-to-moderate LA and 422 patients with severe LA. There were no significant differences in 90-day mRS score between the tirofiban and placebo groups in either stratum (absent-to-moderate LA: adjusted OR 0.92 (95%CI, 0.66–1.28), P = 0.62; severe LA: adjusted OR 0.99 (95% CI, 0.69–1.42), P = 0.96). In the severe LA stratum, the occurrence of radiologic intracranial hemorrhage was greater in the tirofiban group compared to the placebo group. (35.7% vs 26.4%; adjusted OR, 1.72 (95% CI, 1.12–2.66); P = 0.014). However, no difference was observed in the absent-to-moderate LA stratum (33.2% vs 29.3%; adjusted OR, 1.15 (95% CI, 0.76–1.75); P = 0.51). Conclusion: There was no significant difference in disability severity at 90 days when treating AIS patients using intravenous tirofiban before endovascular therapy, in either absent-to-moderate or severe LA strata. It should be noted that intravenous tirofiban before endovascular therapy increases the incidence of radiologic intracranial hemorrhage in patients with severe LA. | |
| dc.language.iso | EN | |
| dc.publisher | Elsevier | |
| dc.subject.lcc | Medicine (General) | |
| dc.title | Leukoaraiosis in patients with tirofiban before endovascular thrombectomy: A post hoc analysis of a multicentre randomized clinical trial | |
| dc.type | Article | |
| dc.description.keywords | Acute ischemic stroke | |
| dc.description.keywords | Leukoaraiosis | |
| dc.description.keywords | Endovascular thrombectomy | |
| dc.description.keywords | Tirofiban | |
| dc.description.pages | 816-824 | |
| dc.description.doi | 10.1016/j.jfma.2024.08.023 | |
| dc.title.journal | Journal of the Formosan Medical Association | |
| dc.identifier.oai | oai:doaj.org/journal:27771187ba5043a6a62e0bb2270ca604 | |
| dc.journal.info | Volume 124, Issue 9 | |
