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Complex visual cognitive function based on a large-scale neurovascular and metabolic coupling mechanisms model in whole brain

dc.contributor.authorTongna Wang
dc.contributor.authorBao Li
dc.contributor.authorYoujun Liu
dc.contributor.authorRuoyao Xu
dc.contributor.authorYuejuan Xu
dc.contributor.authorYang Yang
dc.contributor.authorLiyuan Zhang
dc.contributor.otherDepartment of Biomedical Engineering, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing 100124, China
dc.contributor.otherDepartment of Biomedical Engineering, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing 100124, China
dc.contributor.otherDepartment of Biomedical Engineering, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing 100124, China
dc.contributor.otherDepartment of Biomedical Engineering, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing 100124, China
dc.contributor.otherDepartment of Biomedical Engineering, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing 100124, China
dc.contributor.otherDepartment of Biomedical Engineering, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing 100124, China
dc.contributor.otherDepartment of Biomedical Engineering, Beijing University of Technology, 100 Pingleyuan, Chaoyang District, Beijing 100124, China
dc.date.accessioned2025-08-27T02:01:48Z
dc.date.accessioned2025-10-08T09:21:58Z
dc.date.available2025-10-08T09:21:58Z
dc.date.issued01-04-2025
dc.identifier.urihttps://www.aimspress.com/article/doi/10.3934/era.2025107
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/40085
dc.description.abstractThe neurovascular and metabolic coupling (NVMC) mechanism constitutes a critical physiological foundation for visual information processing. However, multimodal studies remain confined to phenomenological descriptions and fail to provide deeper theoretical investigations, preventing precise assessment of individuals. To address these limitations, we developed a heterogeneous whole-brain computational model of NVMC that integrates task-based EEG-MRI-fMRI multimodal data to simulate the cascading processes from neural mass firing to metabolic-hemodynamic responses. The model was validated against 33 resting-state simultaneous EEG-fMRI datasets. It was found that at the regional level, the fusiform exhibited stronger functional connectivity associated with face recognition, and its NVMC (CBF/FCS) demonstrated statistically significant differences between face stimuli (famous and unfamiliar faces) and scrambled faces (P < 0.001). Whole brain level analyses revealed reduced NVMC (CBF-FCS) with increasing face regularity and familiarity, despite nonsignificant differences in network indices. Subnetwork-level investigations further identified pronounced heterogeneity in functional interactions across distinct neural circuits. In this study, we developed a whole-brain-scale computational model to investigate the heterogeneity of NVMC during face-specific stimulus processing. The model provides an interpretable computational framework for enabling personalized assessments of visual cognitive tasks.
dc.language.isoEN
dc.publisherAIMS Press
dc.subject.lccMathematics
dc.titleComplex visual cognitive function based on a large-scale neurovascular and metabolic coupling mechanisms model in whole brain
dc.typeArticle
dc.description.keywordsneurovascular and metabolic coupling
dc.description.keywordsneurodynamic response
dc.description.keywordshemodynamics
dc.description.keywordsvisual stimulation
dc.description.keywordswhole-brain-scale computational model
dc.description.pages2412-2432
dc.description.doi10.3934/era.2025107
dc.title.journalElectronic Research Archive
dc.identifier.e-issn2688-1594
dc.identifier.oaioai:doaj.org/journal:b46207cd5c924b0ab7ba609c854fff87
dc.journal.infoVolume 33, Issue 4


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