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Identification, pathogenicity and molecular characterization of a novel fowl adenovirus 8b strain

dc.contributor.authorYapeng Song
dc.contributor.authorLin Liu
dc.contributor.authorWenjie Sun
dc.contributor.authorWenming Gao
dc.contributor.authorXiaonan Song
dc.contributor.authorYang Wang
dc.contributor.authorQiang Wei
dc.contributor.authorZongmei Huang
dc.contributor.authorXinsheng Li
dc.contributor.otherCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, China
dc.contributor.otherCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, China
dc.contributor.otherCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, China
dc.contributor.otherCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, China
dc.contributor.otherCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, China
dc.contributor.otherCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, China
dc.contributor.otherHenan Provincial Key Laboratory of Animal Immunology, Henan Academy of Agricultural Sciences, Zhengzhou, 450002, China
dc.contributor.otherCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, China
dc.contributor.otherCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou, 450002, China; Corresponding author:
dc.date.accessioned2024-04-12T04:44:15Z
dc.date.accessioned2025-10-08T09:26:17Z
dc.date.available2025-10-08T09:26:17Z
dc.date.issued01-06-2024
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/40392
dc.description.abstractABSTRACT: Since 2012, there has been a noticeable upward trend in the global incidence of inclusion body hepatitis (IBH) cases, leading to substantial economic losses in the poultry industry. In response to this trend, the current study aimed to investigate the phylogenetic information, genetic mutations, and pathogenicity of the highly pathogenic fowl adenovirus (FAdV) strain HN1472, which was isolated from liver samples obtained from a laying flock affected by IBH. This investigation was carried out using 1-day-old specific pathogen-free (SPF) chickens. Recombination and phylogenetic analyses confirmed that HN1472 is a recombinant strain derived from FAdV-8a and FAdV-8b, and exhibited significant genetic divergence in the hexon, fiber, and ORF19 genes. Notably, the phylogenetic analysis identified recombination events in these regions. Furthermore, animal experiments revealed that HN1472 is a highly pathogenic isolate, causing 80% mortality and manifesting clinical signs of IBH in SPF chickens. Furthermore, the recombinant FAdV serotype 8b (FAdV-8b) was found to be widely distributed in various tissues, with a higher concentration in the livers and gizzard tissue at 3 d postchallenge (dpc). Collectively, these findings contribute to our current understanding of the factors influencing the pathogenicity and genetic diversity of FAdV serotype 8b (FAdV-8b) in China.
dc.language.isoEN
dc.publisherElsevier
dc.subject.lccAnimal culture
dc.titleIdentification, pathogenicity and molecular characterization of a novel fowl adenovirus 8b strain
dc.typeArticle
dc.description.keywordsfowl adenovirus
dc.description.keywordsisolation
dc.description.keywordsrecombination
dc.description.keywordsidentification
dc.description.keywordspathogenicity
dc.description.doi10.1016/j.psj.2024.103725
dc.title.journalPoultry Science
dc.identifier.oaioai:doaj.org/journal:57d0cc3651174aeba1aeb54b69354461
dc.journal.infoVolume 103, Issue 6


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