Show simple item record

An injectable pH neutral bioactive glass-based bone cement with suitable bone regeneration ability

dc.contributor.authorXibing Zhang
dc.contributor.authorYanlin Chen
dc.contributor.authorJiaming Fu
dc.contributor.authorQiuhong Chen
dc.contributor.authorYang Li
dc.contributor.authorCanliang Fang
dc.contributor.authorChenglong Li
dc.contributor.authorLiang Wang
dc.contributor.authorDong Qiu
dc.contributor.authorZhongmin Zhang
dc.contributor.otherDepartment of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Academy of Orthopedics, Guangzhou, 510630, PR China
dc.contributor.otherDivision of Spine Surgery, Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510080, PR China
dc.contributor.otherDepartment of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Academy of Orthopedics, Guangzhou, 510630, PR China
dc.contributor.otherDepartment of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Academy of Orthopedics, Guangzhou, 510630, PR China
dc.contributor.otherSongshan Lake Materials Laboratory, Dongguan, Guangdong, 523808, PR China
dc.contributor.otherSongshan Lake Materials Laboratory, Dongguan, Guangdong, 523808, PR China
dc.contributor.otherDivision of Spine Surgery, Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510080, PR China
dc.contributor.otherDepartment of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Academy of Orthopedics, Guangzhou, 510630, PR China
dc.contributor.otherBeijing National Laboratory for Molecular Sciences, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, PR China; University of Chinese Academy of Sciences, Beijing, 100190, PR China; Corresponding author. University of Chinese Academy of Sciences, Beijing, 100190, PR China.
dc.contributor.otherDepartment of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Academy of Orthopedics, Guangzhou, 510630, PR China; Division of Spine Surgery, Department of Orthopedics, Nanfang Hospital, Southern Medical University, Guangzhou, 510080, PR China; Corresponding author. Department of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Academy of Orthopedics, Guangzhou, 510630, PR China.
dc.date.accessioned2025-10-09T04:35:48Z
dc.date.available2025-10-09T04:35:48Z
dc.date.issued01-09-2022
dc.identifier.urihttp://www.sciencedirect.com/science/article/pii/S2214031X22000481
dc.identifier.urihttp://digilib.fisipol.ugm.ac.id/repo/handle/15717717/40709
dc.description.abstractBackground: As a class of promising bone augmentation materials, bone cements have attracted particular attention. Due to various limitations, the current bone cements are still imperfect. In this study, an injectable pH neutral bioactive bone cement (PSC/CSC) was developed by mixing phosphosilicate bioactive glass (PSC) and α-calcium sulfate hemihydrate (CSH), with the goal of optimizing bone defects repairs. Methods: A range of compositions (PSC/CSC: 10P/90C, 30P/70C, 50P/50C) were developed and their physicochemical properties evaluated. Their bone regeneration ability was compared to those of two widely used bone cements as controls (calcium phosphate cement (CPC) and Genex®) in rabbit femoral condyle bone defect models for 4, 8 and 12 weeks. Based on physicochemical properties and in vivo bone regeneration ability, the PSC/CSC exhibited the best outcomes was selected. Then, in vitro, the effects of selected PSC/CSC, CPC and Genex® extracts on MC3T3-E1 cell proliferation, migration and osteogenesis as well as angiogenesis of HUVECs were examined. Results: Based on physicochemical properties, the 30P/70C formula exhibited suitable operability and compressive strength (3.5 ± 0.3 MPa), which fulfilled the requirements for cancellous bone substitutes. In vivo, findings from micro-CT and histological analyses showed that the 30P/70C formula better promoted bone regeneration, compared to 10P/90C, 50P/50C, CPC and Genex®. Hence, 30P/70C was selected as the ideal PSC-based cement. In vitro, the 30P/70C extracts showed better promotion of cell viability, alkaline phosphatase (ALP) activity, calcium mineral deposition, mRNA and protein expression levels of osteogenesis in MC3T3-E1 cells, further supporting its superiority. Meanwhile, the 30P/70C extracts also showed better stimulation of HUVECs proliferation and angiogenesis. Conclusion: The new composite cement, 30P/70C, is a favorable bioactive glass-based bone cement with suitable operability, compressive strength and bone regeneration ability. The translational potential of this article: Clinically, treatment of large bone defects is still a major challenge for orthopaedic trauma. We showed that 30P/70C has the potential to be clinically used as an injectable cement for rapid bone repairs and reconstruction of critical sized bone defects.
dc.language.isoEN
dc.publisherElsevier
dc.subject.lccDiseases of the musculoskeletal system
dc.titleAn injectable pH neutral bioactive glass-based bone cement with suitable bone regeneration ability
dc.typeArticle
dc.description.keywordsBone regeneration
dc.description.keywordsBioactive glass
dc.description.keywordsInjectable bone cement
dc.description.keywordsNeutral pH
dc.description.pages120-131
dc.description.doi10.1016/j.jot.2022.05.011
dc.title.journalJournal of Orthopaedic Translation
dc.identifier.oaioai:doaj.org/journal:1ca06ad2b9fe486da6d4f850bf0d9c14


This item appears in the following Collection(s)

Show simple item record